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dc.creatorAgmon-Levin, Nancy 
dc.creatorRam, Maya 
dc.creatorBarzilai, Ori 
dc.creatorPorat-Katz, Bat sheva 
dc.creatorParikman, Ronit 
dc.creatorSelmi, Carlo 
dc.creatorGershwin, M. Eric 
dc.creatorAnaya, Juan-Manuel 
dc.creatorYouinou, Pierre 
dc.creatorBizzaro, Nicola 
dc.creatorTincani, Angela 
dc.creatorTzioufas, Athanasios G. 
dc.creatorCervera, Ricard 
dc.creatorStojanovich, Ljudmila 
dc.creatorMartin, Javier 
dc.creatorGonzalez-Gay, Miguel Angel 
dc.creatorValentini, Gabriele 
dc.creatorBlank, Miri 
dc.creatorSanMarco, Marielle 
dc.creatorRozman, Blaž 
dc.creatorBombardieri, Stefano 
dc.creatorDe Vita, Salvatore 
dc.creatorShoenfeld, Yehuda 
dc.date.accessioned2020-05-25T23:55:53Z
dc.date.available2020-05-25T23:55:53Z
dc.date.created2009
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22250
dc.description.abstract"Objective: To evaluate the prevalence of serum antibodies against hepatitis C virus and other infectious agents in a large cohort of well-characterized patients with autoimmune diseases (AID). Methods: We utilized 1322 sera from patients with 18 different AID and 236 sera from healthy controls from the same countries and with similar age and sex distribution. All sera were tested for the presence of serum anti-hepatitis C virus (HCV) antibodies as well as antibodies directed at other infectious agents and autoantibodies. Results: Anti-HCV antibody was detected in 115/1322 (8.7%) of patients with AID and 0.4% of matched healthy controls (P less than 0.0001). The prevalence of anti-HCV antibody was significantly higher in 7/18 different AID (i.e. cryoglobulinemia, mixed cryoglobulinemia pemphigus vulgaris, vasculitis, secondary anti-phospholipid syndrome, Hashimoto's thyroiditis, and inflammatory bowel disease) compared to controls. Patients with AID and serum anti-HCV positivity had an increased prevalence of antibodies against hepatitis B virus, Toxoplasma gondii and Cytomegalovirus as opposed to a lower frequency of serum autoantibodies. Conclusions: The enhanced prevalence of anti-HCV serum antibodies in AID may suggest a role for HCV in tolerance to breakdown, similarly to its established role in mixed cryoglobulinemia. This immune mediated effect does not rule out the role of other infectious agents. © 2009."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.32, No.43924 (2009); pp. 261-266
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-67349203916&doi=10.1016%2fj.jaut.2009.02.017&partnerID=40&md5=79b8ae1b17a7f3c3734257402578bd23
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titlePrevalence of hepatitis C serum antibody in autoimmune diseases
dc.typearticle
dc.subject.keywordAutoantibody
dc.subject.keywordCytomegalovirus antibody
dc.subject.keywordHepatitis b antibody
dc.subject.keywordHepatitis c antibody
dc.subject.keywordProtozoon antibody
dc.subject.keywordAntibody detection
dc.subject.keywordAntiphospholipid syndrome
dc.subject.keywordArticle
dc.subject.keywordAutoimmune disease
dc.subject.keywordChurg strauss syndrome
dc.subject.keywordControlled study
dc.subject.keywordCryoglobulinemia
dc.subject.keywordDiabetes mellitus
dc.subject.keywordEnteritis
dc.subject.keywordGiant cell arteritis
dc.subject.keywordHashimoto disease
dc.subject.keywordHepatitis c
dc.subject.keywordHepatitis c virus
dc.subject.keywordHuman
dc.subject.keywordMajor clinical study
dc.subject.keywordMicroscopic polyangiitis
dc.subject.keywordMultiple sclerosis
dc.subject.keywordMyositis
dc.subject.keywordPemphigus vulgaris
dc.subject.keywordPrevalence
dc.subject.keywordPrimary biliary cirrhosis
dc.subject.keywordPriority journal
dc.subject.keywordRheumatoid arthritis
dc.subject.keywordSjoegren syndrome
dc.subject.keywordSystemic lupus erythematosus
dc.subject.keywordToxoplasma gondii
dc.subject.keywordWegener granulomatosis
dc.subject.keywordAged
dc.subject.keywordAutoantibodies
dc.subject.keywordAutoimmune diseases
dc.subject.keywordFemale
dc.subject.keywordHepatitis c
dc.subject.keywordHepatitis c antibodies
dc.subject.keywordHumans
dc.subject.keywordMale
dc.subject.keywordMiddle aged
dc.subject.keywordPrevalence
dc.subject.keywordAntiphospholipids syndrome
dc.subject.keywordAutoantibodies
dc.subject.keywordAutoimmune diseases
dc.subject.keywordCryoglobulinemia
dc.subject.keywordHepatitis-c
dc.subject.keywordInflammatory bowel diseases
dc.subject.keywordPemphigus vulgaris
dc.subject.keywordThyroid autoimmune diseases
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2009.02.017
dc.relation.citationEndPage266
dc.relation.citationIssueNo. 43924
dc.relation.citationStartPage261
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 32


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