Sjögren's syndrome at the crossroad of polyautoimmunity
AuthorAmador-Patarroyo, Manuel J.
Arbelaez, Juan Guillermo
Mantilla, Ruben D.
Guarin, Mayra R.
Kleine, Liliana Lopez
The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases. © 2012 Elsevier Ltd.
Adult ; autoimmune ; rheumatoid ; spontaneous ; Antiphospholipid syndrome ; systemic ; Article ; Autoimmune disease ; Autoimmune hepatitis ; Autoimmune thyroiditis ; Cigarette smoking ; Comorbidity ; Cross-sectional study ; Disease duration ; Enteritis ; Female ; Human ; Major clinical study ; Male ; Multiple sclerosis ; Pernicious anemia ; Prevalence ; Priority journal ; Psoriasis ; Rheumatoid arthritis ; Risk factor ; Sjoegren syndrome ; Spontaneous abortion ; Systemic lupus erythematosus ; Systemic sclerosis ; Vasculitis ; Vitiligo ; Abortion ; Adult ; Arthritis ; Autoantibodies ; Cross-sectional studies ; Female ; Humans ; Inflammatory bowel diseases ; Lupus erythematosus ; Male ; Middle aged ; Pregnancy ; Regression analysis ; Risk factors ; Sjogren's syndrome ; Smoking ; Thyroiditis ; Abortion ; Autoimmune disease ; Multiple autoimmune syndrome ; Polyautoimmunity ; Sjögren's syndrome ; Smoking ;
- Artículos