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dc.creatorMolano-González, Nicolas 
dc.creatorRojas, Manuel 
dc.creatorMonsalve, Diana M. 
dc.creatorPacheco Nieva, Yovana 
dc.creatorAcosta-Ampudia, Yeny 
dc.creatorRodríguez, Yhojan 
dc.creatorRodríguez-Jímenez, Mónica 
dc.creatorRamirez-Santana, Carolina 
dc.creatorAnaya, Juan-Manuel 
dc.date.accessioned2020-05-25T23:55:55Z
dc.date.available2020-05-25T23:55:55Z
dc.date.created2019
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22263
dc.description.abstractAutoimmune diseases (ADs) are a chronic and clinically heterogeneous group of diseases characterized by share common immunopathogenic mechanisms and risk factors (i.e., the autoimmune tautology), which explain the fact that one AD may coexist with others (i.e., polyautoimmunity - PolyA). In the present exploratory study, a mixed-cluster analysis of the most common autoimmune rheumatic diseases (ARDs) was done. A total of 187 consecutive women with established systemic lupus erythematosus (n = 70), rheumatoid arthritis (n = 51), systemic sclerosis (n = 35) and Sjögren's syndrome (n = 31) were included. A comprehensive clinical, autoantibody and cytokine assessment was simultaneously done. Total PolyA was registered in 142 (75.9%) patients. Six clusters were obtained, built mainly on autoantibodies: PolyA-I to -VI. The PolyA-III cluster showed the highest frequency of overt PolyA (p = 0.01), and the PolyA-I, -III, and -IV clusters exhibited the highest positivity for IL-12/23p40 (p = 0.015). These results provide new insights into the pathophysiology of PolyA and warrant prospective validation to enable development of a more accurate taxonomy of ARDs. © 2018 The Authors
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.98,(2019); pp. 24-32
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056602650&doi=10.1016%2fj.jaut.2018.11.002&partnerID=40&md5=57791f14737e0d657b9a97fe62973ed0
dc.titleCluster analysis of autoimmune rheumatic diseases based on autoantibodies. New insights for polyautoimmunity
dc.typearticle
dc.publisherAcademic Press
dc.subject.keywordAlpha interferon
dc.subject.keywordAutoantibody
dc.subject.keywordGamma interferon
dc.subject.keywordGranulocyte colony stimulating factor
dc.subject.keywordImmunoglobulin g
dc.subject.keywordImmunoglobulin m
dc.subject.keywordInterleukin 10
dc.subject.keywordInterleukin 12
dc.subject.keywordInterleukin 13
dc.subject.keywordInterleukin 17
dc.subject.keywordInterleukin 1beta
dc.subject.keywordInterleukin 2
dc.subject.keywordInterleukin 4
dc.subject.keywordInterleukin 5
dc.subject.keywordInterleukin 6
dc.subject.keywordInterleukin 8
dc.subject.keywordInterleukin 9
dc.subject.keywordTumor necrosis factor
dc.subject.keywordAdult
dc.subject.keywordAntiphospholipid syndrome
dc.subject.keywordArticle
dc.subject.keywordAutoimmune disease
dc.subject.keywordAutoimmune hepatitis
dc.subject.keywordCluster analysis
dc.subject.keywordControlled study
dc.subject.keywordDisease duration
dc.subject.keywordFemale
dc.subject.keywordHuman
dc.subject.keywordMajor clinical study
dc.subject.keywordMyasthenia gravis
dc.subject.keywordOnset age
dc.subject.keywordPathophysiology
dc.subject.keywordPriority journal
dc.subject.keywordProspective study
dc.subject.keywordRheumatic disease
dc.subject.keywordRheumatoid arthritis
dc.subject.keywordRisk factor
dc.subject.keywordSjoegren syndrome
dc.subject.keywordSystemic lupus erythematosus
dc.subject.keywordSystemic sclerosis
dc.subject.keywordInterleukin-12/23p40
dc.subject.keywordRheumatoid arthritis
dc.subject.keywordSjögren's syndrome
dc.subject.keywordSystemic lupus erythematosus
dc.subject.keywordSystemic sclerosis
dc.subject.keywordTaxonomy
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2018.11.002
dc.relation.citationEndPage32
dc.relation.citationStartPage24
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 98
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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