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dc.creatorGutierrez-Alvarez, Angela M. 
dc.creatorBeltrán-Rodríguez, Johnny 
dc.creatorMoreno, Carlos B. 
dc.date.accessioned2020-05-25T23:56:24Z
dc.date.available2020-05-25T23:56:24Z
dc.date.created2007
dc.identifier.issn8853924
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22414
dc.description.abstractPain is frequent in diabetic neuropathy and is very hard to manage. Antiepileptic drugs have been used in treating pain for several decades. Their effectiveness has been described in different types of neuropathic pain, but when used as analgesics in painful diabetic neuropathy it still remains controversial. To clarify this effectiveness, a meta-analysis was performed to determine which antiepileptic drug had the best analgesic potential for managing pain in patients suffering from painful diabetic neuropathy. The search covered the Cochrane, MEDLINE, EMBASE, and LILACS databases, between January 1966 and September 2005. The following information was obtained from each article: criteria for diagnosing diabetic neuropathy, patients' age average, antiepileptic drug received and dose, sample size, duration of the disease and treatment follow-up, outcome measurement, evaluation of pain, and rescue medication. A combined 2.33 relative risk (95% confidence interval [CI] 1.88-2.88) was obtained; this result indicated that the antiepileptic drugs studied were effective for controlling pain in diabetic neuropathy. The corresponding necessary number to treat (NNT) values were established for evaluating which antiepileptic drug was most effective as an analgesic, according to our interests; pregabalin was shown to be the antiepileptic drug having the lowest NNT (NNT = 3.24 and 95% CI 2.12-6.81) for achieving greater than 50% analgesia in patients suffering from painful diabetic neuropathy. Antiepileptic drugs are frequently used in the specific case of diabetic neuropathy; the combined result of this meta-analysis has demonstrated their analgesic benefit. © 2007 U.S. Cancer Pain Relief Committee.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofJournal of Pain and Symptom Management, ISSN:8853924, Vol.34, No.2 (2007); pp. 201-208
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34447625700&doi=10.1016%2fj.jpainsymman.2006.10.023&partnerID=40&md5=31fc696f8e97313b0b7bc736afbb3194
dc.titleAntiepileptic Drugs in Treatment of Pain Caused by Diabetic Neuropathy
dc.typearticle
dc.subject.keywordAnticonvulsive agent
dc.subject.keywordCarbamazepine
dc.subject.keywordGabapentin
dc.subject.keywordLamotrigine
dc.subject.keywordOxcarbazepine
dc.subject.keywordPhenytoin
dc.subject.keywordPregabalin
dc.subject.keywordTopiramate
dc.subject.keywordValproic acid
dc.subject.keywordAge distribution
dc.subject.keywordAnalgesic activity
dc.subject.keywordClinical trial
dc.subject.keywordCochrane library
dc.subject.keywordDiabetic neuropathy
dc.subject.keywordDisease duration
dc.subject.keywordDrug efficacy
dc.subject.keywordDrug indication
dc.subject.keywordEmbase
dc.subject.keywordFollow up
dc.subject.keywordHuman
dc.subject.keywordMedline
dc.subject.keywordMeta analysis
dc.subject.keywordNeuropathic pain
dc.subject.keywordOutcome assessment
dc.subject.keywordPain assessment
dc.subject.keywordReview
dc.subject.keywordSample size
dc.subject.keywordSystematic review
dc.subject.keywordAnticonvulsants
dc.subject.keywordDiabetic neuropathies
dc.subject.keywordHumans
dc.subject.keywordNeuralgia
dc.subject.keywordAnticonvulsants
dc.subject.keywordDiabetic neuropathies
dc.subject.keywordMeta-analysis
dc.subject.keywordNeuropathy
dc.subject.keywordPain
dc.subject.keywordRandomized controlled trials
dc.subject.keywordTreatment
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.jpainsymman.2006.10.023
dc.relation.citationEndPage208
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage201
dc.relation.citationTitleJournal of Pain and Symptom Management
dc.relation.citationVolumeVol. 34
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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