Show simple item record

dc.creatorLaissue, Paul 
dc.date.accessioned2020-05-25T23:57:06Z
dc.date.available2020-05-25T23:57:06Z
dc.date.created2019
dc.identifier.issn14764598
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22607
dc.description.abstractColorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. These changes are key determinants regarding tumour's behaviour as they contribute to cell differentiation/proliferation, migration and metastasis, as well as resistance to chemotherapeutic agents. The forkhead box (FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life. Their dysfunction has been associated with human diseases. Several FOX gene subgroup transcriptional disturbances, affecting numerous complex molecular cascades, have been linked to a wide range of cancer types highlighting their potential usefulness as molecular biomarkers. At least 14 FOX subgroups have been related to CRC pathogenesis, thereby underlining their role for diagnosis, prognosis and treatment purposes. This manuscript aims to provide, for the first time, a comprehensive review of FOX genes' roles during CRC pathogenesis. The molecular and functional characteristics of most relevant FOX molecules (FOXO, FOXM1, FOXP3) have been described within the context of CRC biology, including their usefulness regarding diagnosis and prognosis. Potential CRC therapeutics (including genome-editing approaches) involving FOX regulation have also been included. Taken together, the information provided here should enable a better understanding of FOX genes' function in CRC pathogenesis for basic science researchers and clinicians. © 2019 The Author(s).
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofMolecular Cancer, ISSN:14764598, Vol.18, No.1 (2019)
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059797841&doi=10.1186%2fs12943-019-0938-x&partnerID=40&md5=f1d0f005866696a8bfed98cf5af1e6e1
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleThe forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology
dc.typearticle
dc.publisherBioMed Central Ltd.
dc.subject.keywordCisplatin
dc.subject.keywordneoplastic
dc.subject.keywordForkhead box protein m1
dc.subject.keywordForkhead transcription factor
dc.subject.keywordOncoprotein
dc.subject.keywordTranscription factor foxo
dc.subject.keywordTranscription factor foxp3
dc.subject.keywordForkhead transcription factor
dc.subject.keywordAkt1 gene
dc.subject.keywordAkt2 gene
dc.subject.keywordApoptosis
dc.subject.keywordBinding affinity
dc.subject.keywordCancer cell
dc.subject.keywordCancer diagnosis
dc.subject.keywordCancer growth
dc.subject.keywordCancer research
dc.subject.keywordCell cycle g1 phase
dc.subject.keywordCell cycle g2 phase
dc.subject.keywordCell cycle m phase
dc.subject.keywordCell cycle regulation
dc.subject.keywordCell cycle s phase
dc.subject.keywordCell proliferation
dc.subject.keywordClinical research
dc.subject.keywordColon carcinogenesis
dc.subject.keywordColorectal cancer
dc.subject.keywordCrispr-cas9 system
dc.subject.keywordDna binding
dc.subject.keywordFox gene
dc.subject.keywordFoxm1 gene
dc.subject.keywordFoxo gene
dc.subject.keywordFoxp3 gene
dc.subject.keywordGene editing
dc.subject.keywordGene expression regulation
dc.subject.keywordGene function
dc.subject.keywordHuman
dc.subject.keywordImmunity
dc.subject.keywordLymphocytic infiltration
dc.subject.keywordNonhuman
dc.subject.keywordPdpk1 gene
dc.subject.keywordProtein phosphorylation
dc.subject.keywordRegulatory t lymphocyte
dc.subject.keywordReview
dc.subject.keywordScience
dc.subject.keywordTranscription regulation
dc.subject.keywordTumor microenvironment
dc.subject.keywordTumor suppressor gene
dc.subject.keywordAnimal
dc.subject.keywordCell motion
dc.subject.keywordColorectal tumor
dc.subject.keywordGenetics
dc.subject.keywordPathology
dc.subject.keywordPrognosis
dc.subject.keywordAnimals
dc.subject.keywordCell movement
dc.subject.keywordCell proliferation
dc.subject.keywordColorectal neoplasms
dc.subject.keywordForkhead transcription factors
dc.subject.keywordGene expression regulation
dc.subject.keywordHumans
dc.subject.keywordPrognosis
dc.subject.keywordColorectal cancer
dc.subject.keywordForkhead transcription factors
dc.subject.keywordMolecular aetiology
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1186/s12943-019-0938-x
dc.title.TranslatedTitleThe forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology
dc.relation.citationIssueNo. 1
dc.relation.citationTitleMolecular Cancer
dc.relation.citationVolumeVol. 18


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record