Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature
Purpose: To review the literature on tubulointerstitial nephritis and uveitis (TINU) syndrome, and to report a case of a patient with relapsing polychondritis (RP) and TINU syndrome. Method: TINU syndrome is a rare oculorenal inflammatory disorder. It is more common in young women with autoimmune conditions, infections, systemic disease, and previous use of medications. We report the case of a 62-year-old woman with relapsing polychondritis and a 2-year history of acute, recurrent, asymmetric, bilateral, anterior, non-granulomatous uveitis accompanied by tubulointerstitial nephritis. Results: The patient was diagnosed with TINU syndrome associated with relapsing polychondritis. No cases of this association have been reported in the literature. The clinical features of TINU syndrome are discussed based on the published works. Conclusions: TINU is an uncommon syndrome; only about 200 cases have been reported in the literature related to infections, systemic disease, and previous use of medications such as antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). We found that it can be associated with relapsing polychondritis; therefore, it is important to investigate symptoms of this disease since TINU syndrome can co-exist with it. © 2015 Taylor and Francis Group, LLC.
Azathioprine ; Beta 2 microglobulin ; relapsing ; relapsing ; non-steroidal ; interstitial ; interstitial ; Cyclosporin ; Deflazacort ; Infliximab ; Mydriatic agent ; Prednisolone ; Rheumatoid factor ; Steroid ; Urea ; Uric acid ; Glucocorticoid ; Nonsteroid antiinflammatory agent ; Adult ; Autoimmune disease ; Bronchitis ; Cartilaginous tissue ; Case report ; Cataract ; Chronic cough ; Clinical feature ; Conjunctival hyperemia ; Coughing ; Creatinine blood level ; Disease association ; Dizziness ; Drug treatment failure ; Dry skin ; Eye examination ; Fatigue ; Female ; Focal glomerulosclerosis ; Human ; Human cell ; Human tissue ; Infection ; Inflammatory cell ; Interstitial nephritis ; Kidney biopsy ; Kidney dysfunction ; Long term care ; Middle aged ; Pain ; Perception deafness ; Recurrent disease ; Relapsing polychondritis ; Review ; Rhinitis ; Sedimentation rate ; Sleep disorder ; Steroid therapy ; Subcapsular cataract ; Systemic disease ; Systemic therapy ; Tinnitus ; Topical treatment ; Treatment duration ; Tubulointerstitial nephritis and uveitis syndrome ; Urinalysis ; Uveitis ; Vertigo ; Visual acuity ; Complication ; Nephritis ; Polychondritis ; Uveitis ; Anti-inflammatory agents ; Female ; Glucocorticoids ; Humans ; Middle aged ; Nephritis ; Polychondritis ; Uveitis ; Acute tubulointerstitial nephritis ; Nephropathy ; Relapsing polychondritis ; Tinu syndrome ; Uveitis ;
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