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dc.creatorMartínez, Paola A. 
dc.creatorYandar, Nubia 
dc.creatorLesmes, Liliana P. 
dc.creatorForero, Martha 
dc.creatorPérez-Leal, Oscar 
dc.creatorPatarroyo, Manuel Elkin 
dc.creatorLozano, José Manuel 
dc.date.accessioned2020-05-25T23:58:00Z
dc.date.available2020-05-25T23:58:00Z
dc.date.created2009
dc.identifier.issn1969781
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22784
dc.description.abstractWe have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype switching, these antibodies were tested for their ability to suppress blood-stage parasitemia through passive immunization in malaria-infected mice. Some proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. Protection against P. berghei malaria following Ig passive immunization can be associated with specific immunoglobulins induced by a site-directed designed MSP-2 reduced amide pseudopeptide. © 2008 Elsevier Inc. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPeptides, ISSN:1969781, Vol.30, No.2 (2009); pp. 330-342
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-58149484910&doi=10.1016%2fj.peptides.2008.10.022&partnerID=40&md5=e5477e7d371aea7c48e5732ae309ed1b
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titlePassive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice
dc.typearticle
dc.subject.keywordImmunoglobulin
dc.subject.keywordprotozoan
dc.subject.keywordImmunoglobulin class
dc.subject.keywordMalaria vaccine
dc.subject.keywordMerozoite surface protein 2
dc.subject.keywordMonoclonal antibody
dc.subject.keywordMonoclonal antibody anti pseudopeptide psi 130
dc.subject.keywordPseudopeptide
dc.subject.keywordUnclassified drug
dc.subject.keywordAnimal cell
dc.subject.keywordAnimal experiment
dc.subject.keywordAnimal model
dc.subject.keywordAnimal tissue
dc.subject.keywordArticle
dc.subject.keywordControlled study
dc.subject.keywordDrug design
dc.subject.keywordDrug mechanism
dc.subject.keywordDrug synthesis
dc.subject.keywordFemale
dc.subject.keywordMouse
dc.subject.keywordNonhuman
dc.subject.keywordParasitemia
dc.subject.keywordPassive immunization
dc.subject.keywordPlasmodium berghei infection
dc.subject.keywordPlasmodium falciparum
dc.subject.keywordPriority journal
dc.subject.keywordAnimals
dc.subject.keywordAntibodies, protozoan
dc.subject.keywordAntigens, protozoan
dc.subject.keywordDisease models, animal
dc.subject.keywordFemale
dc.subject.keywordImmunization, passive
dc.subject.keywordMalaria
dc.subject.keywordMice
dc.subject.keywordMice, inbred balb c
dc.subject.keywordParasitemia
dc.subject.keywordPlasmodium berghei
dc.subject.keywordPlasmodium falciparum
dc.subject.keywordProtozoan proteins
dc.subject.keywordRecombinant proteins
dc.subject.keywordMurinae
dc.subject.keywordMus
dc.subject.keywordPlasmodium berghei
dc.subject.keywordPlasmodium falciparum
dc.subject.keywordAnti-malarial vaccine
dc.subject.keywordIg isotype
dc.subject.keywordIn vivo neutralizing activity
dc.subject.keywordMurine malarial infection
dc.subject.keywordPseudopeptide
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.peptides.2008.10.022
dc.relation.citationEndPage342
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage330
dc.relation.citationTitlePeptides
dc.relation.citationVolumeVol. 30


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