"The LUFS domain, its transcriptional regulator proteins, and drug resistance in the fungal pathogen Candida auris"
"The LUFS domain (LUG/LUH, Flo8, single-strand DNA-binding protein [SSBP]) is a well-conserved and apparently ancient region found in diverse proteins and taxa. This domain, which has as its most obvious structural feature a series of three helices, has been identified in transcriptional regulator proteins of animals, plants, and fungi. Recently, in these pages (Wang et al., Protein Sci., 2019, 28:788–793), the first crystal structure of a LUFS domain was reported, for the human SSBP2, a transcriptional repressor. We briefly address how the new insights into LUFS structures might contribute to a better understanding of an important transcriptional activator of yeasts that contains the LUFS domain, Flo8, and consider how a focus on the LUFS domain and its variation could help us to understand etiologies of drug resistance in a recently emerged pathogenic fungus, Candida auris. © 2019 The Protein Society"
Regulator protein ; Single stranded dna binding protein ; Transcription factor ; Article ; Candida auris ; Drug resistance ; Fungal virulence ; Nonhuman ; Priority journal ; Protein domain ; Protein structure ; Structure analysis ; Transcription initiation ; Transcription regulation ; Activation and repression domains ; Amphotericin b ; Antifungal resistance mechanisms ; Candida ; Filamentation in fungi ; Flocculence ; Lufs domain ; Single nucleotide polymorphisms ; Transcription factors ; Whole-genome sequence comparisons ;
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