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dc.creatorSánchez, Elena 
dc.creatorRasmussen, Astrid 
dc.creatorRiba, Laura 
dc.creatorAcevedo?Vasquez, Eduardo 
dc.creatorKelly, Jennifer A. 
dc.creatorLangefeld, Carl D. 
dc.creatorWilliams, Adrianne H. 
dc.creatorZiegler, Julie T. 
dc.creatorComeau, Mary E. 
dc.creatorMarion, Miranda C. 
dc.creatorLa Torre, Ignacio García?De 
dc.creatorMaradiaga?Ceceña, Marco A. 
dc.creatorCardiel, Mario H. 
dc.creatorEsquivel?Valerio, Jorge A. 
dc.creatorRodriguez?Amado, Jacqueline 
dc.creatorMoctezuma, José Francisco 
dc.creatorMiranda, Pedro 
dc.creatorPerandones, Carlos E. 
dc.creatorCastel, Cecilia 
dc.creatorLaborde, Hugo A. 
dc.creatorAlba, Paula 
dc.creatorMusuruana, Jorge L. 
dc.creatorGoecke, I. Annelise 
dc.creatorAnaya, Juan-Manuel 
dc.creatorKaufman, Kenneth M. 
dc.creatorAdler, Adam 
dc.creatorGlenn, Stuart B. 
dc.creatorBrown, Elizabeth E. 
dc.creatorAlarcón, Graciela S. 
dc.creatorKimberly, Robert P. 
dc.creatorEdberg, Jeffrey C. 
dc.creatorVilá, Luis M. 
dc.creatorCriswell, Lindsey A. 
dc.creatorGilkeson, Gary S. 
dc.creatorNiewold, Timothy B. 
dc.creatorMartín, Javier 
dc.creatorVyse, Timothy J. 
dc.creatorBoackle, Susan A. 
dc.creatorRamsey?Goldman, Rosalind 
dc.creatorScofield, R. Hal 
dc.creatorPetri, Michelle 
dc.creatorMerrill, Joan T. 
dc.creatorReveille, John D. 
dc.creatorTsao, Betty P. 
dc.creatorOrozco, Lorena 
dc.creatorBaca, Vicente 
dc.creatorMoser, Kathy L. 
dc.creatorGaffney, Patrick M. 
dc.creatorJames, Judith A. 
dc.creatorHarley, John B. 
dc.creatorTusié?Luna, Teresa 
dc.creatorPons?Estel, Bernardo A. 
dc.creatorJacob, Chaim O. 
dc.creatorAlarcón?Riquelme, Marta E. 
dc.date.accessioned2020-05-25T23:59:04Z
dc.date.available2020-05-25T23:59:04Z
dc.date.created2012
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22977
dc.description.abstract"Objective American Indian-Europeans, Asians, and African Americans have an excess morbidity from systemic lupus erythematosus (SLE) and a higher prevalence of lupus nephritis than do Caucasians. The aim of this study was to analyze the relationship between genetic ancestry and sociodemographic characteristics and clinical features in a large cohort of American Indian-European SLE patients. Methods A total of 2,116 SLE patients of American Indian-European origin and 4,001 SLE patients of European descent for whom we had clinical data were included in the study. Genotyping of 253 continental ancestry-informative markers was performed on the Illumina platform. Structure and Admixture software were used to determine genetic ancestry proportions of each individual. Logistic regression was used to test the association between genetic ancestry and sociodemographic and clinical characteristics. Odds ratios (ORs) were calculated with 95% confidence intervals (95% CIs). Results The average American Indian genetic ancestry of 2,116 SLE patients was 40.7%. American Indian genetic ancestry conferred increased risks of renal involvement (P less than 0.0001, OR 3.50 [95% CI 2.63- 4.63]) and early age at onset (P less than 0.0001). American Indian ancestry protected against photosensitivity (P less than 0.0001, OR 0.58 [95% CI 0.44-0.76]), oral ulcers (P less than 0.0001, OR 0.55 [95% CI 0.42-0.72]), and serositis (P less than 0.0001, OR 0.56 [95% CI 0.41-0.75]) after adjustment for age, sex, and age at onset. However, age and sex had stronger effects than genetic ancestry on malar rash, discoid rash, arthritis, and neurologic involvement. Conclusion In general, American Indian genetic ancestry correlates with lower sociodemographic status and increases the risk of developing renal involvement and SLE at an earlier age. Copyright © 2012 by the American College of Rheumatology."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofArthritis and Rheumatism, Vol.64, No.11 (2012); pp. 3687-3694
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84868092719&doi=10.1002%2fart.34650&partnerID=40&md5=523678b9426ee9ae333c83fa81beb18f
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleImpact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations
dc.typearticle
dc.subject.keywordAfrica
dc.subject.keywordSystemic
dc.subject.keywordAmerican Indian
dc.subject.keywordNorth American
dc.subject.keywordSouth American
dc.subject.keywordArthritis
dc.subject.keywordArticle
dc.subject.keywordAsian
dc.subject.keywordDemography
dc.subject.keywordDiscoid rash
dc.subject.keywordEurope
dc.subject.keywordGenetic analysis
dc.subject.keywordGenetic association
dc.subject.keywordGenetic risk
dc.subject.keywordGenetic screening
dc.subject.keywordGenotyping technique
dc.subject.keywordHematologic disease
dc.subject.keywordHeredity
dc.subject.keywordHuman
dc.subject.keywordInflammation
dc.subject.keywordKidney disease
dc.subject.keywordMajor clinical study
dc.subject.keywordMalar rash
dc.subject.keywordMouth ulcer
dc.subject.keywordNeurologic disease
dc.subject.keywordOnset age
dc.subject.keywordPhotosensitivity
dc.subject.keywordPopulation genetics
dc.subject.keywordPriority journal
dc.subject.keywordRisk assessment
dc.subject.keywordSkin disease
dc.subject.keywordSystemic lupus erythematosus
dc.subject.keywordAdolescent
dc.subject.keywordAdult
dc.subject.keywordChild
dc.subject.keywordEuropean Continental Ancestry Group
dc.subject.keywordFemale
dc.subject.keywordGenetic Predisposition to Disease
dc.subject.keywordGenotype
dc.subject.keywordHumans
dc.subject.keywordIndians
dc.subject.keywordIndians
dc.subject.keywordLupus Erythematosus
dc.subject.keywordLupus Nephritis
dc.subject.keywordMale
dc.subject.keywordMiddle Aged
dc.subject.keywordMorbidity
dc.subject.keywordPrevalence
dc.subject.keywordRisk Factors
dc.subject.keywordSocioeconomic Factors
dc.subject.keywordYoung Adult
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1002/art.34650
dc.relation.citationEndPage3694
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage3687
dc.relation.citationTitleArthritis and Rheumatism
dc.relation.citationVolumeVol. 64


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