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dc.creatorMolano-González, Nicolas 
dc.creatorOlivares-Martínez E. 
dc.creatorAnaya, Juan-Manuel 
dc.creatorHernández-Molina G. 
dc.date.accessioned2020-05-26T00:00:47Z
dc.date.available2020-05-26T00:00:47Z
dc.date.created2019
dc.identifier.issn15027732
dc.identifier.issn03009742
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23271
dc.description.abstract"Objective: The presence of anti-citrullinated protein antibodies (ACPAs) in primary Sjögren’s syndrome (pSS) ranges from 3% to 9.9%; however, there is no agreement about their clinical significance. Our aim was to systematically review the literature regarding the association of arthritis and ACPAs in pSS and their role in the development of rheumatoid arthritis (RA). Method: A comprehensive search of MEDLINE, ISI Web of Knowledge, and Cochrane Library from inception until June 2016 was undertaken using the combination of two or three of the keywords: primary Sjögren’s syndrome, Sjögren’s syndrome, arthritis, synovitis, arthropathy, anti-cyclic citrullinated peptide antibodies, and anti-citrullinated protein antibody–ACPA. No language restriction was used. Studies were included if they: assessed the association of arthritis and ACPAs, had sufficient data to construct a two-by-two table, tested immunoglobulin G ACPA by any method, and included patients with pSS according to a validated set of classification criteria. We used a random effects model and evaluated the heterogeneity and publication bias. Results: Ten studies were included (involving 1322 patients). We found a pooled odds ratio of 4.42 (95% confidence interval 1.15–16.94, p = 0.03). The test for heterogeneity was I 2  = 0.87. Publication bias was not observed. Based on data from three studies, 33 of 58 pSS patients with ACPAs (57%) developed RA compared with none of 598 pSS patients with negative ACPA (p  and lt; 0.000001). Conclusion: Patients with pSS disclosing ACPAs are prone to arthritis as part of the clinical spectrum of the disease, but are also at risk of developing RA. © 2019, © 2019 Informa Healthcare on license from Scandinavian Rheumatology Research Foundation."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofScandinavian Journal of Rheumatology, ISSN:15027732, 03009742, Vol.48, No.2 (2019); pp. 157-163
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85054341329&doi=10.1080%2f03009742.2018.1469164&partnerID=40&md5=d83ddd2de37c041cdffa7c262c17ba42
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleAnti-citrullinated protein antibodies and arthritis in Sjögren’s syndrome: a systematic review and meta-analysis
dc.typearticle
dc.publisherTaylor and Francis Ltd
dc.subject.keywordCyclic citrullinated peptide antibody
dc.subject.keywordrheumatoid
dc.subject.keywordImmunoglobulin g
dc.subject.keywordCyclic citrullinated peptide antibody
dc.subject.keywordArthritis
dc.subject.keywordArthropathy
dc.subject.keywordArticle
dc.subject.keywordCochrane library
dc.subject.keywordHuman
dc.subject.keywordMedline
dc.subject.keywordPriority journal
dc.subject.keywordRheumatoid arthritis
dc.subject.keywordSjoegren syndrome
dc.subject.keywordSynovitis
dc.subject.keywordSystematic review
dc.subject.keywordWeb of science
dc.subject.keywordComplication
dc.subject.keywordImmunology
dc.subject.keywordMeta analysis
dc.subject.keywordSjoegren syndrome
dc.subject.keywordAnti-citrullinated protein antibodies
dc.subject.keywordArthritis
dc.subject.keywordHumans
dc.subject.keywordSjogren's syndrome
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1080/03009742.2018.1469164
dc.relation.citationEndPage163
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage157
dc.relation.citationTitleScandinavian Journal of Rheumatology
dc.relation.citationVolumeVol. 48


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