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HLA class II polymorphism in Latin American patients with multiple sclerosis

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Rojas, Olga-Lucía
Rojas-Villarraga, Adriana
Cruz-Tapias, Paola
Sánchez, Jorge Luis
Suárez-Escudero, Juan-Camilo
Patarroyo, Manuel-Alfonso
Anaya, Juan-Manuel

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2010

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Abstract
Objective: To identify HLA-DRB1 alleles contributing to susceptibility to multiple sclerosis (MS) in a Colombian population and to estimate the common effect size of HLA class II on MS susceptibility in Latin American populations through a meta-analysis. Methods: A total of 65 Colombian patients with MS and 184 matched controls were included. HLA-DRB1 typing was done using the sequence-specific oligonucleotide probe method. A bivariate and a multivariate logistic regression analyses were done. Case-control studies performed in Latin America were searched up to January 2009 through a systematic review of the literature. Effect summary odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by means of the random effect model. Results: A total of 464 cases and 2581 controls from 7 studies and the results of the present study in Colombians were analyzed. HLA-DRB1*15 (OR: 2.3; 95% CI: 1.68-3.07; p and lt; 0.001) and HLA-DQB1*06 (OR: 2.2; 95% CI: 1.54-3.07; p and lt; 0.001) groups as well as DRB1*1501 (OR: 2.6; 95% CI: 1.67-4.02; p and lt; 0.001), DRB1*1503 (OR: 2.2; 95% CI: 1.39-3.62; p = 0.001) and DQB1*0602 (OR: 2.5; 95% CI: 1.66-3.71; p and lt; 0.001) alleles were found to be risk factors for MS. The myelin basic protein immunodominant sequence 221VHFFKNIVT229 was predicted to strongly and simultaneously bind to HLA-DRB1*1501 and *1503. Conclusion: The current study highlights the effect size of HLA class II in MS in Latin America and confirms similar allelic risk factors across diverse populations. Receptor-ligand interactions in the HLA-antigenic peptide complex could have potential predictive and therapeutical implications. © 2009 Elsevier B.V. All rights reserved.
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HLA antigen class 2 , Genetic , HLA DR antigen , Myelin basic protein , Adult , Allele , Antigen binding , Case control study , Colombia , Controlled study , Disease predisposition , DNA extraction , DNA polymorphism , Female , Gene identification , Genetic risk , Human , Major clinical study , Male , Multiple sclerosis , Nucleotide sequence , Oligonucleotide probe , Review , Risk , Autoantigens , Case-Control Studies , Colombia , Female , Gene Frequency , Genetic Association Studies , Genetic Predisposition to Disease , Histocompatibility Testing , HLA-DQ Antigens , HLA-DR Antigens , Humans , Male , Multiple Sclerosis , Myelin Basic Proteins , Peptide Fragments , Polymorphism , Protein Binding , Risk Factors , HLA antigens , Latin America , Meta-analysis , Multiple sclerosis , Myelin basic protein
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