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dc.creatorAngel, Diana I. 
dc.creatorMongui, Alvaro 
dc.creatorArdila-Montealegre, Javier 
dc.creatorVanegas, Magnolia 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2020-05-26T00:02:34Z
dc.date.available2020-05-26T00:02:34Z
dc.date.created2008
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23503
dc.description.abstractRecently, Plasmodium vivax has been related to nearly 81% of malaria cases reported in Central America and the Mediterranean. Due to the difficulty of culturing this parasite species in vitro, most studies on P. vivax have focused on the identification of new antigens by homology comparison with P. falciparum vaccine candidate proteins. In this study, we have identified and characterized a Pf41 homologue in P. vivax, hence named Pv41, by following such approach and using web-available bioinformatics databases, molecular techniques and immunochemistry assays. Pv41 protein is a 384-amino-acid-long antigen encoded by a single exon that exhibits two s48/45 domains characteristic of gametocyte surface proteins. We have also demonstrated Pv41 transcription and expression during late intra-erythrocytic parasite stages and defined its subcellular localization on the parasite surface. © 2008 Elsevier Inc. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.377, No.4 (2008); pp. 1113-1117
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-56349090489&doi=10.1016%2fj.bbrc.2008.10.129&partnerID=40&md5=2dcf940f872febf2803087c367924603
dc.titleThe Plasmodium vivax Pv41 surface protein: Identification and characterization
dc.typearticle
dc.subject.keywordAmino acid
dc.subject.keywordAntigen
dc.subject.keywordmolecular
dc.subject.keywordgenetic
dc.subject.keywordtertiary
dc.subject.keywordprotozoan
dc.subject.keywordMembrane protein
dc.subject.keywordProtozoal protein
dc.subject.keywordArticle
dc.subject.keywordBioinformatics
dc.subject.keywordCellular distribution
dc.subject.keywordData base
dc.subject.keywordExon
dc.subject.keywordGametocyte
dc.subject.keywordImmunohistochemistry
dc.subject.keywordLife cycle
dc.subject.keywordNonhuman
dc.subject.keywordPlasmodium vivax
dc.subject.keywordPriority journal
dc.subject.keywordProtein analysis
dc.subject.keywordProtein determination
dc.subject.keywordProtein domain
dc.subject.keywordProtein expression
dc.subject.keywordAmino acid sequence
dc.subject.keywordAnimals
dc.subject.keywordAntigens
dc.subject.keywordCell membrane
dc.subject.keywordCloning
dc.subject.keywordErythrocytes
dc.subject.keywordExons
dc.subject.keywordMembrane proteins
dc.subject.keywordPlasmodium vivax
dc.subject.keywordProtein structure
dc.subject.keywordProtozoan proteins
dc.subject.keywordRabbits
dc.subject.keywordTranscription
dc.subject.keywordPlasmodium falciparum
dc.subject.keywordPlasmodium vivax
dc.subject.keywordBioinformatics
dc.subject.keywordMalaria
dc.subject.keywordPlasmodium vivax
dc.subject.keywordPv41
dc.subject.keywordSix-cys domain
dc.subject.keywordVaccine candidate
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2008.10.129
dc.relation.citationEndPage1117
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage1113
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 377
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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