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Sternal osteomyelitis and scrofuloderma due to BCG vaccination
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Corrales I.F.
Cortés J.A.
Mesa M.L.
Zamora G.
Fecha
2003
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Abstract
BCG vaccine has been used for nearly 100 years in the prevention of tuberculosis. The case of a 13 month-old girl vaccinated as a newborn with BCG is described as presenting a sternal mass with associated periostic erosion. The mass was resected, and histopathological examination revealed a chronic inflammatory reaction with caseous granulomas, and extension to bone and skin. PCR amplifications using specific primers for Mycobacterium tuberculosis on paraffin-embedded tissue were negative. BCG vaccination at birth, the histological appearance and the absence of M. tuberculosis DNA in the resected tissue indicated that osteomyelitis and scrofuloderma were a consequence of BCG. Osteomyelitis is a rarely occurring adverse effect of BCG vaccination, more commonly seen in immunosuppressed patients. In the patient described above, no symptoms of immunodeficiency were seen, however.
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Bacterial DNA , BCG vaccine , Article , Case report , Female , Genetics , Human , Infant , Isolation and purification , Microbiology , Mycobacterium tuberculosis , Osteomyelitis , Pathology , Polymerase chain reaction , Skin tuberculosis , Sternum , Tuberculous arthritis , Vaccination , BCG Vaccine , DNA , Female , Humans , Infant , Mycobacterium tuberculosis , Osteomyelitis , Polymerase Chain Reaction , Sternum , Tuberculosis , Tuberculosis , Vaccination
