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dc.creatorCruz-Saavedra, Lissa 
dc.creatorDíaz-Roa, Andrea 
dc.creatorGaona, María A. 
dc.creatorCruz, Mónica L. 
dc.creatorAyala, Martha 
dc.creatorCortés-Vecino, Jesús A. 
dc.creatorPatarroyo, Manuel A. 
dc.creatorBello, Felio J. 
dc.date.accessioned2020-05-26T00:04:09Z
dc.date.available2020-05-26T00:04:09Z
dc.date.created2016
dc.identifier.issn0001706X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23663
dc.description.abstractThis study's main objective was to evaluate the action of larval therapy derived from Lucilia sericata and Sarconesiopsis magellanica (blowflies) regarding Leishmania panamensis using an in vivo model. Eighteen golden hamsters (Mesocricetus auratus) were used; they were divided into 6 groups. The first three groups consisted of 4 animals each; these, in turn, were internally distributed into subgroups consisting of 2 hamsters to be used separately in treatments derived from each blowfly species. Group 1 was used in treating leishmanial lesions with larval therapy (LT), whilst the other two groups were used for evaluating the used of larval excretions and secretions (ES) after the ulcers had formed (group 2) and before they appeared (group 3). The three remaining groups (4, 5 and 6), consisting of two animals, were used as controls in the experiments. Biopsies were taken for histopathological and molecular analysis before, during and after the treatments; biopsies and smears were taken for assessing parasite presence and bacterial co-infection. LT and larval ES proved effective in treating the ulcers caused by the parasite. There were no statistically significant differences between the blowfly species regarding the ulcer cicatrisation parameters. There were granulomas in samples taken from lesions at the end of the treatments. The antibacterial action of larval treatment regarding co-infection in lesions caused by the parasite was also verified. These results potentially validate effective LT treatment against cutaneous leishmaniasis aimed at using it with humans in the future. © 2016 Elsevier B.V.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofActa Tropica, ISSN:0001706X, Vol.164,(2016); pp. 280-289
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84989179388&doi=10.1016%2fj.actatropica.2016.09.020&partnerID=40&md5=9226cb2a5bf9da6828288f2a78aec7a1
dc.titleThe effect of Lucilia sericata- and Sarconesiopsis magellanica-derived larval therapy on Leishmania panamensis
dc.typearticle
dc.publisherElsevier B.V.
dc.subject.keywordExperimental study
dc.subject.keywordcutaneous
dc.subject.keywordcutaneous
dc.subject.keywordFly
dc.subject.keywordHistopathology
dc.subject.keywordLarva
dc.subject.keywordParasite
dc.subject.keywordRodent
dc.subject.keywordAnimal experiment
dc.subject.keywordAnimal model
dc.subject.keywordAnimal tissue
dc.subject.keywordAntibacterial activity
dc.subject.keywordArticle
dc.subject.keywordCalliphoridae
dc.subject.keywordClinical effectiveness
dc.subject.keywordControlled study
dc.subject.keywordDisease severity
dc.subject.keywordEscherichia coli infection
dc.subject.keywordIn vivo study
dc.subject.keywordKlebsiella pneumoniae infection
dc.subject.keywordLeishmania panamensis
dc.subject.keywordLucilia sericata
dc.subject.keywordMaggot therapy
dc.subject.keywordMixed infection
dc.subject.keywordNonhuman
dc.subject.keywordSarconesiopsis magellanica
dc.subject.keywordScar formation
dc.subject.keywordSkin leishmaniasis
dc.subject.keywordSkin ulcer
dc.subject.keywordSyrian hamster
dc.subject.keywordAnimal
dc.subject.keywordBiological therapy
dc.subject.keywordDebridement
dc.subject.keywordDiptera
dc.subject.keywordHuman
dc.subject.keywordLarva
dc.subject.keywordLeishmania guyanensis
dc.subject.keywordLeishmaniasis
dc.subject.keywordMesocricetus
dc.subject.keywordMixed infection
dc.subject.keywordParasitology
dc.subject.keywordProcedures
dc.subject.keywordSecretion (process)
dc.subject.keywordTreatment outcome
dc.subject.keywordUlcer
dc.subject.keywordAnimalia
dc.subject.keywordBacteria (microorganisms)
dc.subject.keywordCalliphoridae
dc.subject.keywordCricetinae
dc.subject.keywordLeishmania panamensis
dc.subject.keywordLucilia sericata
dc.subject.keywordMesocricetus auratus
dc.subject.keywordAntiinfective agent
dc.subject.keywordInsect protein
dc.subject.keywordAnimals
dc.subject.keywordAnti-bacterial agents
dc.subject.keywordBiological therapy
dc.subject.keywordCoinfection
dc.subject.keywordDebridement
dc.subject.keywordDiptera
dc.subject.keywordHumans
dc.subject.keywordInsect proteins
dc.subject.keywordLarva
dc.subject.keywordLeishmania guyanensis
dc.subject.keywordLeishmaniasis
dc.subject.keywordMesocricetus
dc.subject.keywordTreatment outcome
dc.subject.keywordUlcer
dc.subject.keywordCo-infection
dc.subject.keywordHamster
dc.subject.keywordLarval excretions and secretions
dc.subject.keywordLarval therapy
dc.subject.keywordLeishmania panamensis
dc.subject.keywordLucilia sericata
dc.subject.keywordSarconesiopsis magellanica
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2016.09.020
dc.relation.citationEndPage289
dc.relation.citationStartPage280
dc.relation.citationTitleActa Tropica
dc.relation.citationVolumeVol. 164
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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