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dc.creatorCifuentes, Ricardo A. 
dc.creatorCruz-Tapias, Paola 
dc.creatorRojas-Villarraga, Adriana 
dc.creatorAnaya, Juan-Manuel 
dc.date.accessioned2020-05-26T00:04:10Z
dc.date.available2020-05-26T00:04:10Z
dc.date.created2010
dc.identifier.issn98981
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23664
dc.description.abstract"Background: ZC3H12A is a gene whose absence is related to autoimmune disorders and to other phenotypical alterations. Methods: A comprehensive review of the structure, molecular functions and regulation of ZC3H12A gene and its protein MCPIP1 is done in order to understand their clinical implications. Results: ZC3H12A, at 1p34.3, has 9860 bp, six exons and 61 described SNPs. Eleven are non-synonymous thus leading to changes in MCPIP1, the protein encoded by ZC3H12A. MCPIP1 is induced by MCP-1 and IL-1 whose signals are transduced through the NF-k? and MAPkinase pathways. This protein acts as an RNAse by degrading chemokine transcripts such as IL-1 as well as its own mRNA and as a transcription factor by reducing the expression of other chemokines induced by NF-k? such as MCP-1. It also up-regulates genes involved in several differentiation processes and apoptosis. Therefore, ZC3H12A is an equilibrium gatekeeper that not only regulates its own inducers but also controls the regulation by degrading its own mRNA. Conclusion: Understanding ZC3H12A gives a comprehensive panorama that promises to improve our understanding of processes in which this gene is involved including autoimmune, infectious and cardiovascular diseases. © 2010 Elsevier B.V."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofClinica Chimica Acta, ISSN:98981, Vol.411, No.23-24 (2010); pp. 1862-1868
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77957754481&doi=10.1016%2fj.cca.2010.08.033&partnerID=40&md5=5584894f3101666d64f6031940c88bdc
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleZC3H12A (MCPIP1): Molecular characteristics and clinical implications
dc.typearticle
dc.subject.keywordImmunoglobulin enhancer binding protein
dc.subject.keywordInterleukin 1
dc.subject.keywordMessenger rna
dc.subject.keywordMitogen activated protein kinase
dc.subject.keywordMonocyte chemotactic protein 1
dc.subject.keywordMonocyte chemotactic protein 1 induced protein
dc.subject.keywordUnclassified drug
dc.subject.keywordZinc finger protein
dc.subject.keywordApoptosis
dc.subject.keywordAutoimmune disease
dc.subject.keywordCardiovascular disease
dc.subject.keywordGene control
dc.subject.keywordGene function
dc.subject.keywordGene structure
dc.subject.keywordGenetic regulation
dc.subject.keywordGenetic variability
dc.subject.keywordHuman
dc.subject.keywordInfection
dc.subject.keywordMolecular genetics
dc.subject.keywordNonhuman
dc.subject.keywordNucleotide sequence
dc.subject.keywordPriority journal
dc.subject.keywordProtein degradation
dc.subject.keywordProtein expression
dc.subject.keywordProtein function
dc.subject.keywordReview
dc.subject.keywordSignal transduction
dc.subject.keywordSingle nucleotide polymorphism
dc.subject.keywordUpregulation
dc.subject.keywordAnimals
dc.subject.keywordDisease
dc.subject.keywordHumans
dc.subject.keywordTranscription factors
dc.subject.keywordPyronia tithonus
dc.subject.keywordApoptosis
dc.subject.keywordAutoimmune diseases
dc.subject.keywordCardiac diseases
dc.subject.keywordGenetics
dc.subject.keywordMcpip1
dc.subject.keywordZc3h12a
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.cca.2010.08.033
dc.relation.citationEndPage1868
dc.relation.citationIssueNo. 23-24
dc.relation.citationStartPage1862
dc.relation.citationTitleClinica Chimica Acta
dc.relation.citationVolumeVol. 411


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