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dc.creatorZhao, Jian 
dc.creatorWu, Hui 
dc.creatorLangefeld, Carl D. 
dc.creatorKaufman, Kenneth M. 
dc.creatorKelly, Jennifer A. 
dc.creatorBae, Sang-Cheol 
dc.creatornetworks, Marta E. Alarcón-Riquelme for the BIOLUPUS and GENLES 
dc.creatorAlarcón, Graciela S. 
dc.creatorAnaya, Juan-Manuel 
dc.creatorCriswell, Lindsey A. 
dc.creatorFreedman, Barry I. 
dc.creatorKamen, Diane L. 
dc.creatorGilkeson, Gary S. 
dc.creatorJacob, Chaim O. 
dc.creatorJames, Judith A. 
dc.creatorMerrill, Joan T. 
dc.creatorGaffney, Patrick M. 
dc.creatorSivils, Kathy Moser 
dc.creatorNiewold, Timothy B. 
dc.creatorPetri, Michelle 
dc.creatorSong, Seung Taek 
dc.creatorJeong, Hye-jin 
dc.creatorRamsey-Goldman, Rosalind 
dc.creatorReveille, John D. 
dc.creatorScofield, R. Hal 
dc.creatorStevens, Anne M. 
dc.creatorBoackle, Susan A. 
dc.creatorVilá, Luis M. 
dc.creatorChang, Deh-Ming 
dc.creatorSong, Yeong Wook 
dc.creatorVyse, Timothy J. 
dc.creatorHarley, John B. 
dc.creatorBrown, Elizabeth E. 
dc.creatorEdberg, Jeffrey C. 
dc.creatorKimberly, Robert P. 
dc.creatorHahn, Bevra H. 
dc.creatorGrossman, Jennifer M. 
dc.creatorTsao, Betty P. 
dc.creatorLa Cava, Antonio 
dc.date.accessioned2020-05-26T00:04:25Z
dc.date.available2020-05-26T00:04:25Z
dc.date.created2015
dc.identifier.issn15217035
dc.identifier.issn15216616
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23683
dc.description.abstract"Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE. © 2015 Elsevier Inc."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofClinical Immunology, ISSN:15217035, 15216616, Vol.161, No.2 (2015); pp. 157-162
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84942900473&doi=10.1016%2fj.clim.2015.09.007&partnerID=40&md5=f534aa6109e09fb0476e966fa4d201c2
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleGenetic associations of leptin-related polymorphisms with systemic lupus erythematosus
dc.typearticle
dc.publisherAcademic Press Inc.
dc.subject.keywordLeptin
dc.subject.keywordsystemic
dc.subject.keywordLeptin
dc.subject.keywordsingle nucleotide
dc.subject.keywordAfrican american
dc.subject.keywordArticle
dc.subject.keywordControlled study
dc.subject.keywordDna determination
dc.subject.keywordEast asian
dc.subject.keywordEuropean american
dc.subject.keywordGene
dc.subject.keywordGenetic association
dc.subject.keywordGenetic risk
dc.subject.keywordGenetic susceptibility
dc.subject.keywordGenotype
dc.subject.keywordGhsr gene
dc.subject.keywordHispanic
dc.subject.keywordHuman
dc.subject.keywordInflammation
dc.subject.keywordLep gene
dc.subject.keywordLepr gene
dc.subject.keywordMajor clinical study
dc.subject.keywordPparg gene
dc.subject.keywordPriority journal
dc.subject.keywordSingle nucleotide polymorphism
dc.subject.keywordSystemic lupus erythematosus
dc.subject.keywordCase control study
dc.subject.keywordGenetic predisposition
dc.subject.keywordGenetics
dc.subject.keywordSingle nucleotide polymorphism
dc.subject.keywordSystemic lupus erythematosus
dc.subject.keywordCase-control studies
dc.subject.keywordGenetic predisposition to disease
dc.subject.keywordGenotype
dc.subject.keywordHumans
dc.subject.keywordLeptin
dc.subject.keywordLupus erythematosus
dc.subject.keywordPolymorphism
dc.subject.keywordGene polymorphisms
dc.subject.keywordLeptin pathway
dc.subject.keywordSystemic lupus erythematosus
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.clim.2015.09.007
dc.relation.citationEndPage162
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage157
dc.relation.citationTitleClinical Immunology
dc.relation.citationVolumeVol. 161


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