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Systemic sclerosis: A world wide global analysis
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Coral-Alvarado, Paola
Pardo, Aryce L.
Castaño-Rodriguez, Natalia
Rojas-Villarraga, Adriana
Anaya, Juan-Manuel
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2009
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Abstract
The objective of this study was to analyze epidemiological tendencies of systemic sclerosis (SSc) around the world in order to identify possible local variations in the presentation and occurrence of the disease. A systematic review of the literature was performed through electronic databases using the keywords 'Systemic Sclerosis' and 'Clinical Characteristics.' Out of a total of 167 articles, 41 were included in the analysis. Significant differences in the mean age at the time of diagnosis, subsets of SSc, clinical characteristics, and presence of antibodies were found between different regions of the word. Because variations in both additive and nonadditive genetic factors and the environmental variance are specific to the investigated population, ethnicity and geography are important characteristics to be considered in the study of SSc and other autoimmune diseases. © Clinical Rheumatology 2009.
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Keywords
Antinuclear antibody , animal , Centromere antibody , systemic , Enzyme antibody , Topoisomerase i antibody , Unclassified drug , Antibody detection , Arthropathy , Article , Calcinosis , Clinical feature , Diffuse cutaneous systemic sclerosis , Disease association , Environmental factor , Esophagus disease , Ethnic difference , Gastrointestinal disease , Genetic variability , Geographic distribution , Heart disease , Human , Kidney disease , Limited cutaneous systemic sclerosis , Lung disease , Onset age , Priority journal , Raynaud phenomenon , Scleroderma , Sex difference , Skin ulcer , Systematic review , Systemic sclerosis , Telangiectasia , Adult , Age factors , Animals , Autoimmunity , Disease models , Environment , Ethnic groups , Female , Genetic predisposition to disease , Humans , Male , Middle aged , Scleroderma , Sex factors , World health , Clinical characteristics , Epidemiology , Systemic sclerosis
