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dc.creatorPatino, Luz H. 
dc.creatorMuskus, Carlos 
dc.creatorMuñoz, Marina 
dc.creatorRamírez, Juan David 
dc.date.accessioned2020-05-26T00:04:48Z
dc.date.available2020-05-26T00:04:48Z
dc.date.created2020
dc.identifier.issn0001706X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23719
dc.description.abstract"Leishmania amazonensis is one of the causative agents of the different forms of cutaneous leishmaniasis present in Latin America. This species has been isolated from humans and animals (canine/feline) in some endemic regions of Colombia. Therefore, L. amazonensis is of great relevance at the clinical and epidemiological levels in medicine and veterinary science. Until now, very few genomes from this species are available. Here, we report the complete genome sequence of a laboratory-adapted L. amazonensis strain isolated from a human patient with clinical manifestation of cutaneous leishmaniasis in Colombia. The genome sequence not only allowed inter and intra-species comparative analyses to be performed with the sequenced genomes of L. amazonensis strains from different geographical regions, but also increased our knowledge about the genomic behavior of this L. amazonensis Colombian strain. This isolate was also characterized in terms of single nucleotide polymorphisms, chromosome and gene copy number variations (CNVs). The results revealed moderate aneuploidy, CNVs in genes involved in the virulence, growth, and survival of the parasite, and in the distributions of the multicopy genes on some chromosomes, as well as a high level of heterozygosity. The data confirmed previous reports that identified unique variations in L. amazonensis, suggesting aneuploidy may not have a high fitness cost and may allow the rapid generation of diversity in Leishmania parasites growing normally. © 2019 Elsevier B.V."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofActa Tropica, ISSN:0001706X, Vol.203,(2020)
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85077322210&doi=10.1016%2fj.actatropica.2019.105296&partnerID=40&md5=c8abe2a6e2e6ef111342546bf1ac7f20
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.title"Genomic analyses reveal moderate levels of ploidy, high heterozygosity and structural variations in a Colombian isolate of Leishmania (Leishmania) amazonensis"
dc.typearticle
dc.publisherElsevier B.V.
dc.subject.keywordEpidemiology
dc.subject.keywordGenetic variation
dc.subject.keywordGenomics
dc.subject.keywordHeterozygosity
dc.subject.keywordLeishmaniasis
dc.subject.keywordParasite
dc.subject.keywordPloidy
dc.subject.keywordAneuploidy
dc.subject.keywordArticle
dc.subject.keywordChromosome variant
dc.subject.keywordColombia
dc.subject.keywordControlled study
dc.subject.keywordCopy number variation
dc.subject.keywordGenetic variation
dc.subject.keywordGenome analysis
dc.subject.keywordHeterozygosity
dc.subject.keywordLeishmania amazonensis
dc.subject.keywordNonhuman
dc.subject.keywordParasite development
dc.subject.keywordParasite survival
dc.subject.keywordParasite virulence
dc.subject.keywordPhylogeny
dc.subject.keywordPloidy
dc.subject.keywordSingle nucleotide polymorphism
dc.subject.keywordSpecies comparison
dc.subject.keywordWhole genome sequencing
dc.subject.keywordColombia
dc.subject.keywordAnimalia
dc.subject.keywordLeishmania amazonensis
dc.subject.keywordAneuploidy
dc.subject.keywordCopy number variation
dc.subject.keywordDiversity
dc.subject.keywordDna-seq
dc.subject.keywordGenome sequencing
dc.subject.keywordL
dc.subject.keywordAmazonensis
dc.subject.keywordParasites
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.actatropica.2019.105296
dc.relation.citationTitleActa Tropica
dc.relation.citationVolumeVol. 203


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