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dc.creatorLozano J.M. 
dc.creatorPatarroyo M.E. 
dc.date.accessioned2020-05-26T00:05:37Z
dc.date.available2020-05-26T00:05:37Z
dc.date.created2013
dc.identifier.issn15733955
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23810
dc.description.abstract"The molecular basis for obtaining novel anti-malarial vaccine candidates depends on a considered selection of antigenic peptides, mainly derived from Plasmodium antigens' non-polymorphic regions. Since such targeted-molecules are poorly immunogenic when tested as vaccine components, they usually have to be modified to overcome their immunological phenotype. Transition state theory, explaining how peptidases catalyse a given peptide bond breakage, thus led to reduced amide pseudopeptides being proposed as possible mimetics for a transition-state. Stabilising such high-energy molecular stages could become a strategy for inducing antibodies potentially harbouring catalytic properties. Hence, isostere-bond peptido-mimetics represented a rational choice as potential abzyme-inducers and site-directed designed reduced amide pseudopeptides for obtaining peptide-analogues from selected malarial high-binding motifs. This novel family of vaccine candidates has proved to be an efficient functional antibody-inducer, the latter acting as efficient blockers of Plasmodium infection of human and mouse RBCs. © 2013 Bentham Science Publishers."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofCurrent Immunology Reviews, ISSN:15733955, Vol.9, No.4 (2013); pp. 261-275
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84900810092&doi=10.2174%2f1573395510666140401180738&partnerID=40&md5=1996fa48a6b02b66616178dfe32576b8
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleTowards a poly-functional synthetic-antimalarial vaccine: Incorporating non-natural elements into artificially-made peptides for mimicking functional pathogen ligand structures representing new site-directed vaccine components
dc.typearticle
dc.publisherBentham Science Publishers B.V.
dc.subject.keywordAmide pseudopeptide
dc.subject.keywordEpitope
dc.subject.keywordMalaria vaccine
dc.subject.keywordMerozoite surface protein 2
dc.subject.keywordParasite antibody
dc.subject.keywordPeptide vaccine
dc.subject.keywordPeptidomimetic agent
dc.subject.keywordPseudopeptide
dc.subject.keywordSynthetic peptide
dc.subject.keywordUnclassified drug
dc.subject.keywordAntimalarial activity
dc.subject.keywordArticle
dc.subject.keywordErythrocyte
dc.subject.keywordHuman
dc.subject.keywordImmune response
dc.subject.keywordImmunogenicity
dc.subject.keywordImmunoprophylaxis
dc.subject.keywordIn vitro study
dc.subject.keywordMalaria
dc.subject.keywordMalaria falciparum
dc.subject.keywordNonhuman
dc.subject.keywordParasitemia
dc.subject.keywordPassive immunization
dc.subject.keywordPhase transition
dc.subject.keywordPlasmodium (life cycle stage)
dc.subject.keywordPlasmodium falciparum
dc.subject.keywordPriority journal
dc.subject.keywordProtein binding
dc.subject.keywordProtein hydrolysis
dc.subject.keywordProtein motif
dc.subject.keywordProtein targeting
dc.subject.keywordPublic health problem
dc.subject.keywordRodent malaria
dc.subject.keywordVaccine production
dc.subject.keywordAntimalarial vaccine
dc.subject.keywordCatalytic antibody
dc.subject.keywordPassive immunisation
dc.subject.keywordPeptide-bond isostere
dc.subject.keywordPeptido-mimetic
dc.subject.keywordPseudopeptide
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.2174/1573395510666140401180738
dc.relation.citationEndPage275
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage261
dc.relation.citationTitleCurrent Immunology Reviews
dc.relation.citationVolumeVol. 9


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