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dc.creatorBohórquez, Michel David 
dc.creatorOrdoñez, Diego 
dc.creatorSuarez Martinez, Carlos Fernando 
dc.creatorVicente, Belén 
dc.creatorVieira, Carmen 
dc.creatorLópez-Abán, Julio 
dc.creatorMuro, Antonio 
dc.creatorOrdóñez, Iván 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2020-05-26T00:08:26Z
dc.date.available2020-05-26T00:08:26Z
dc.date.created2020
dc.identifier.issn16648021
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24084
dc.description.abstract"Bovine leukocyte antigens (BoLA) have been used as disease markers and immunological traits in cattle due to their primary role in pathogen recognition by the immune system. A higher MHC allele diversity in a population will allow presenting a broader peptide repertoire. However, loss of overall diversity due to domestication process can decrease a population’s peptide repertoire. Within the context of zebu and taurine cattle populations, BoLA-DRB3 genetic diversity in Spanish Morucha and Colombian Normande cattle was analyzed and an approach to estimate functional diversity was performed. Sequence-based typing was used for identifying 29, 23, 27, and 28 alleles in Spanish Morucha, Nariño-, Boyacá-, and Cundinamarca-Normande cattle, respectively. These breeds had remarkably low heterozygosity levels and the Hardy-Weinberg principle revealed significant heterozygote deficiency. FST and DA genetic distance showed that Colombian Normande populations had greater variability than other phenotypically homogeneous breeds, such as Holstein. It was also found that Spanish Morucha cattle were strongly differentiated from other cattle breeds. Spanish Morucha had greater divergence in the peptide-binding region regarding other cattle breeds. However, peptide-binding region covariation indicated that the potential peptide repertoire seemed equivalent among cattle breeds. Despite the genetic divergence observed, the extent of the potential peptide repertoire in the cattle populations studied appears to be similar and thus their pathogen recognition potential should be equivalent, suggesting that functional diversity might persist in the face of bottlenecks imposed by domestication and breeding. © Copyright © 2020 Bohórquez, Ordoñez, Suárez, Vicente, Vieira, López-Abán, Muro, Ordóñez and Patarroyo."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofFrontiers in Genetics, ISSN:16648021, Vol.10,(2020)
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078107738&doi=10.3389%2ffgene.2019.01293&partnerID=40&md5=b0fd1a0ba99f31158872c7c9304f1f17
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleMajor Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
dc.typearticle
dc.publisherFrontiers Media S.A.
dc.subject.keywordMajor histocompatibility antigen class 2
dc.subject.keywordAllele
dc.subject.keywordArticle
dc.subject.keywordBola drb3 gene
dc.subject.keywordCattle breed
dc.subject.keywordColombian normande cattle
dc.subject.keywordControlled study
dc.subject.keywordGene
dc.subject.keywordGene frequency
dc.subject.keywordGene locus
dc.subject.keywordGene sequence
dc.subject.keywordGenetic distance
dc.subject.keywordGenetic parameters
dc.subject.keywordGenetic variability
dc.subject.keywordHardy weinberg equilibrium
dc.subject.keywordHeterozygosity
dc.subject.keywordNonhuman
dc.subject.keywordPopulation distribution
dc.subject.keywordPopulation structure
dc.subject.keywordSpanish morucha cattle
dc.subject.keywordTaurine cattle
dc.subject.keywordZebu
dc.subject.keywordBola-drb3
dc.subject.keywordCattle
dc.subject.keywordGenetic diversity
dc.subject.keywordGenetic resistance
dc.subject.keywordMhc
dc.subject.keywordPeptide-binding region
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.3389/fgene.2019.01293
dc.relation.citationTitleFrontiers in Genetics
dc.relation.citationVolumeVol. 10


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