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dc.creatorLópez, Carolina 
dc.creatorYepes-Pérez, Yoelis 
dc.creatorHincapié-Escobar, Natalia 
dc.creatorDíaz Arévalo, Diana 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2020-05-26T00:08:31Z
dc.date.available2020-05-26T00:08:31Z
dc.date.created2017
dc.identifier.issn16643224
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24090
dc.description.abstractMalaria caused by Plasmodium vivax continues being one of the most important infectious diseases around the world; P. vivax is the second most prevalent species and has the greatest geographic distribution. Developing an effective antimalarial vaccine is considered a relevant control strategy in the search for means of preventing the disease. Studying parasite-expressed proteins, which are essential in host cell invasion, has led to identifying the regions recognized by individuals who are naturally exposed to infection. Furthermore, immunogenicity studies have revealed that such regions can trigger a robust immune response that can inhibit sporozoite (hepatic stage) or merozoite (erythrocyte stage) invasion of a host cell and induce protection. This review provides a synthesis of the most important studies to date concerning the antigenicity and immunogenicity of both synthetic peptide and recombinant protein candidates for a vaccine against malaria produced by P. vivax. © 2017 López, Yepes-Pérez, Hincapié-Escobar, Díaz-Arévalo and Patarroyo.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofFrontiers in Immunology, ISSN:16643224, Vol.8, No.FEB (2017)
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85014341523&doi=10.3389%2ffimmu.2017.00126&partnerID=40&md5=061b587217ac2997fa0bdaf68d6b7f89
dc.titleWhat is known about the immune response induced by Plasmodium vivax malaria vaccine candidates?
dc.typearticle
dc.publisherFrontiers Research Foundation
dc.subject.keywordApical membrane antigen 1
dc.subject.keywordChemokine
dc.subject.keywordCircumsporozoite protein
dc.subject.keywordDuffy binding protein
dc.subject.keywordMalaria vaccine
dc.subject.keywordMerozoite surface protein 3
dc.subject.keywordMerozoite surface protein 9
dc.subject.keywordProtozoal protein
dc.subject.keywordRecombinant protein
dc.subject.keywordSynthetic peptide
dc.subject.keywordTranscription factor
dc.subject.keywordUnclassified drug
dc.subject.keywordAdaptive immunity
dc.subject.keywordAntigen binding
dc.subject.keywordB lymphocyte
dc.subject.keywordCell invasion
dc.subject.keywordDisease severity
dc.subject.keywordGeographic distribution
dc.subject.keywordHelper cell
dc.subject.keywordHost cell
dc.subject.keywordHuman
dc.subject.keywordImmune response
dc.subject.keywordImmunological tolerance
dc.subject.keywordInflammation
dc.subject.keywordInnate immunity
dc.subject.keywordMacrophage activation
dc.subject.keywordMinor histocompatibility complex
dc.subject.keywordNatural killer cell
dc.subject.keywordNeuromuscular blocking
dc.subject.keywordNonhuman
dc.subject.keywordPathogenesis
dc.subject.keywordPhagolysosome
dc.subject.keywordPlasmodium vivax malaria
dc.subject.keywordReview
dc.subject.keywordSerology
dc.subject.keywordSporozoite
dc.subject.keywordT lymphocyte activation
dc.subject.keywordVaccine immunogenicity
dc.subject.keywordAntigenicity
dc.subject.keywordImmune response
dc.subject.keywordImmunogenicity
dc.subject.keywordMalaria
dc.subject.keywordPlasmodium vivax
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.3389/fimmu.2017.00126
dc.relation.citationIssueNo. FEB
dc.relation.citationTitleFrontiers in Immunology
dc.relation.citationVolumeVol. 8
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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