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Identification of the Plasmodium falciparum rhoptry neck protein 5 (PfRON5)
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Curtidor H.
Patiño L.C.
Arévalo-Pinzón G.
Patarroyo M.E.
Patarroyo M.A.
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2011
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Abstract
Gathering knowledge about the proteins involved in erythrocyte invasion by Plasmodium merozoites is the starting point for developing new strategies to control malarial disease. Many of these proteins have been studied in Toxoplasma gondii, where some belonging to the Moving Junction complex have been identified. This complex allows a strong interaction between host cell and parasite membranes, required for parasite invasion. In this genus, four rhoptry proteins (RON2, RON4, RON5 and RON8) and one micronemal protein (TgAMA-1) have been found as part of the complex. In Plasmodium falciparum, RON2 and RON4 have been characterized. In the present study, we identify PfRON5, a ~. 110. kDa protein which is expressed in merozoite and schizont stages of the FCB-2 strain. © 2010 Elsevier B.V.
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Plasmodium falciparum rhoptry neck protein 5 , Protozoal protein , Unclassified drug , Animal cell , Animal experiment , Article , Complex formation , Controlled study , Gene expression , Gene identification , Gene sequence , Host cell , Host parasite interaction , Merozoite , Nonhuman , Nucleotide sequence , Plasmodium falciparum , Priority journal , Protein localization , Schizont , Amino Acid Sequence , Base Sequence , Gene Expression , Merozoites , Molecular Sequence Data , Plasmodium falciparum , Protozoan Proteins , Schizonts , Plasmodium falciparum , Toxoplasma gondii , Erythrocyte invasion , Homology , Malaria , Merozoite , Plasmodium falciparum
