Show simple item record

dc.creatorArevalo, J. Fernando 
dc.creatorGarcia-Amaris, Rafael A. 
dc.creatorRoca, Jose A. 
dc.creatorSanchez, Juan G. 
dc.creatorWu, Lihteh 
dc.creatorBerrocal, Maria H. 
dc.creatorMaia, Mauricio 
dc.creatorGroup, Pan-American Collaborative Retina Study 
dc.date.accessioned2020-08-06T16:20:12Z
dc.date.available2020-08-06T16:20:12Z
dc.date.created2007-12
dc.identifier.issnISSN: 0886-3350
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25914
dc.description.abstractTo determine the feasibility, safety, and clinical effect of primary intravitreal bevacizumab (Avastin) in patients with cystoid macular edema (CME) after cataract surgery. Five institutions in Venezuela, Costa Rica, Puerto Rico, Peru, and Brazil. Twenty-eight eyes of 25 patients treated with at least 1 intravitreal injection of 1.25 mg or 2.50 mg of Avastin participated in this interventional retrospective multicenter study at 5 institutions from 5 countries. Baseline and follow-up visits included Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity testing, optical coherence tomography (OCT) imaging, and ophthalmoscopic examination. The mean follow-up was 32 weeks (range 24 to 52 weeks). Twenty eyes (71.4%) had improved best corrected visual acuity (BCVA) (R2 ETDRS lines), and no eye had worse visual acuity (R2 ETDRS lines). The BCVA remained stable in 8 eyes (28.6%). The mean baseline BCVA was 20/160 (logMAR Z 0.92) and the mean final BCVA, 20/63 (logMAR Z 0.50); the difference was statistically significant (P<.0001). The mean central macular thickness at baseline (466.3 mm; range 208 to 784 mm) decreased significantly (264.5 mm; range 176 to 513 mm) by the end of follow-up (P<.0001). Eight eyes (28.6%) required a second injection and 4 (14.3%), a third injection. The mean interval between injections was 13 weeks (range 5 to 26 weeks). No ocular or systemic adverse events were observed. Short-term results suggest that primary intravitreal Avastin is well tolerated in patients with pseudophakic CME. Treated eyes had a significant improvement in BCVA and decrease in macular thickness by OCT.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofJournal of Cataract & Refractive Surgery, ISSN: 0886-3350, Vol.33, No.12 (December, 2007); pp.2098-2105
dc.relation.urihttps://journals.lww.com/jcrs/FullText/2007/12000/Primary_intravitreal_bevacizumab_for_the.35.aspx
dc.sourceJournal of Cataract & Refractive Surgery
dc.titlePrimary intravitreal bevacizumab for the management of pseudophakic cystoid macular edema Pilot study of the Pan-American Collaborative Retina Study Group
dc.typearticle
dc.publisherLippincott Williams & Wilkins (LWW)
dc.subject.keywordAged
dc.subject.keywordAged
dc.subject.keyword80 and over
dc.subject.keywordAngiogenesis Inhibitors
dc.subject.keywordAntibodies
dc.subject.keywordMonoclonal
dc.subject.keywordAntibodies
dc.subject.keywordMonoclonal
dc.subject.keywordHumanized
dc.subject.keywordBevacizumab
dc.subject.keywordCataract Extraction
dc.subject.keywordFeasibility Studies
dc.subject.keywordFemale
dc.subject.keywordHumans
dc.subject.keywordInjections
dc.subject.keywordMacular Edema
dc.subject.keywordMale
dc.subject.keywordMiddle Aged
dc.subject.keywordPilot Projects
dc.subject.keywordPostoperative Complications
dc.subject.keywordPseudophakia
dc.subject.keywordRetreatment
dc.subject.keywordRetrospective Studies
dc.subject.keywordSouth America
dc.subject.keywordTomography
dc.subject.keywordOptical Coherence
dc.subject.keywordVascular Endothelial Growth Factor A
dc.subject.keywordVisual Acuity
dc.subject.keywordVitreous Body
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.type.spaArtículo
dc.rights.accesoRestringido (Acceso a grupos específicos)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.jcrs.2007.07.046
dc.title.TranslatedTitlePilot study of the Pan-American Collaborative Retina Study Group
dc.relation.citationEndPage2105
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage2098
dc.relation.citationTitleJournal of Cataract & Refractive Surgery
dc.relation.citationVolumeVol. 33
dc.creator.OrganizationalPan-American Collaborative Retina Study Group (PACORES) 
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record