Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes

Puentes, Alvaro; García, Javier; Vera, Ricardo; López, Ramsés; Suarez, Jorge; Rodríguez, Luis; Curtidor, Hernando; Ocampo, Marisol; Tovar, Diana; Forero, Martha; Bermudez, Adriana; Cortes, Jimena; Urquiza, Mauricio; Patarroyo, Manuel E.

doi:https://doi.org/10.1016/j.vaccine.2003.09.029

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Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes

https://repository.urosario.edu.co/handle/10336/26992
https://doi.org/10.1016/j.vaccine.2003.09.029

Autores

Puentes, Alvaro

García, Javier

Vera, Ricardo

López, Ramsés

Suarez, Jorge

Rodríguez, Luis

Curtidor, Hernando

Ocampo, Marisol

Tovar, Diana

Forero, Martha

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Fecha

2004-03-12

Editor

The Japanese Society for Vaccinology
Elsevier

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Abstract

Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes.