Show simple item record

dc.creatorZandman-Goddard, G 
dc.creatorBerkun, Y 
dc.creatorBarzilai, O 
dc.creatorBoaz, M 
dc.creatorRam, M 
dc.creatorAnaya, JM 
dc.creatorShoenfeld, Y 
dc.date.accessioned2020-08-28T15:47:56Z
dc.date.available2020-08-28T15:47:56Z
dc.date.created2008-05-01
dc.identifier.issnISSN: 0961-2033
dc.identifier.issnEISSN: 1477-0962
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28310
dc.description.abstractInfections can act as environmental triggers inducing or promoting systemic lupus erythematosus (SLE) in genetically predisposed individuals. The aim of the present study was to compare the titres of antibodies (Abs) to infectious agents with neuropsychiatric (NPSLE) clinical manifestations. The sera of 260 individuals (120 patients with SLE and 140 geographic controls) were evaluated for the titres of Epstein bar virus (EBV), cytomegalovirus (CMV), toxoplasma, rubella and syphilis Abs using the BioPlex 2200 Multiplexed Immunoassay method (BioRad) and by the ELISA method for Helicobacter pylori and Hepatitis B core Ag. All BioPlex 2200 kits used were in developmental stages. Data analysis was performed using SPSS 9.0 statistical analysis software (SPSS Inc., Chicago, IL, USA, 1999). Correlation analysis indicated that rubella IgM Ab titres were marginally, positively associated with psychosis (P = 0.09). No other associations were detected between the 17 infectious Abs and five NP manifestations. When the positivity cut-off for anti-rubella IgM Abs was set at three standard deviations above normal, three positive subjects were identified: one patient with psychosis and one with depression, for a total NPSLE prevalence of 33.3%. On the contrary, the prevalence of NPSLE in the remaining subjects was 6.5%. Marginally significant correlations between elevated titres of rubella IgM Ab with psychosis and depression were found. Although this nearly 5-fold increase is not statistically significant, it appears that in a larger sample size, significance would be reached. This is the first study reported that examined the correlation of NPSLE manifestations with anti-infectious Abs.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofLupus, ISSN: 0961-2033;EISSN: 1477-0962, Vol. 17, No. 5 (2008); pp. 380-384
dc.relation.urihttps://journals.sagepub.com/doi/10.1177/0961203308090017
dc.sourceLupus
dc.titleNeuropsychiatric lupus and infectious triggers
dc.typearticle
dc.publisherSAGE Publications
dc.subject.keywordLupus erythematosus (SLE)
dc.subject.keywordAntibodies
dc.subject.keywordInfectious triggers
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.type.spaArtículo
dc.rights.accesoRestringido (Acceso a grupos específicos)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1177/0961203308090017
dc.title.TranslatedTitleLupus neuropsiquiátrico y desencadenantes infecciosos
dc.relation.citationEndPage384
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage380
dc.relation.citationTitleLupus
dc.relation.citationVolumeVol. 17


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record