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dc.creatorAnaya, Juan-Manuel 
dc.creatorCorre, Paula A. 
dc.creatorHerrera, Monica 
dc.creatorEskdale, Joyce 
dc.creatorGallagher, Grant
dc.identifier.issnISSN: 0315-162X
dc.identifier.issnEISSN: 1499-2752
dc.description.abstractObjective. To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10 microsatellite polymorphism in patients with primary Sjögren’s syndrome (pSS). Methods. Serum IL-10 and autoantibody levels [IgG anti-Ro and anti-La, total and IgA rheumatoid factor (RF)] were measured by ELISA. A minor salivary gland (MSG) biopsy was performed in all patients and the focus score was determined as a measure of salivary gland disease activity. In addition, IL-10 microsatellite typing was performed by polymerase chain reaction technique. Results. IL-10 concentration was higher in patients (n = 39) than in controls (n = 15) (21.4 ± 6.7 vs 2.5 ± 3.5 pg/ml; p = 0.001). We found a significant positive correlation between IL-10 levels and titers of IgA RF, anti-Ro, and anti-La antibodies, as well as focus score. In comparison with patients with low IL-10 production (< 9.5 pg/ml), patients producing high IL-10 had significantly more episodes of cutaneous vasculitis and a higher proportion of them carried the IL-10.G9 allele. Conclusion. Autoimmune response in pSS patients as well as salivary gland disease activity and cutaneous involvement appears to be mediated by IL-10 levels; in turn, there is a linkage with IL-10 gene polymorphism. (J Rheumatol 2002;29:1874–6).
dc.relation.ispartofThe Journal of Rheumatology, ISSN: 0315-162X ; EISSN: 1499-2752, Vol. 29, No. 9 (2002); pp. 1874-1876
dc.sourceThe Journal of Rheumatology
dc.titleInterleukin 10 (IL-10) influences autoimmune response in primary Sj??gren's syndrome and is linked to IL-10 gene polymorphism
dc.publisherThe Journal of Rheumatology Publishing
dc.subject.keywordSjögren’s Syndrome
dc.subject.keywordInterleukin 10
dc.subject.keywordAnti-Ro Antibodies
dc.subject.keywordAnti-La Antibodies
dc.subject.keywordRheumatoid Factor
dc.rights.accesoAbierto (Texto Completo)
dc.title.TranslatedTitleLa interleucina 10 (IL-10) influye en la respuesta autoinmune en el síndrome de Sjögren primario y está relacionada con el polimorfismo del gen IL-10
dc.relation.citationIssueNo. 9
dc.relation.citationTitleThe Journal of Rheumatology
dc.relation.citationVolumeVol. 29
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR

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