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dc.creatorAnaya, Juan-Manuel 
dc.creatorTalal, Norman 
dc.date.accessioned2020-08-28T15:48:09Z
dc.date.available2020-08-28T15:48:09Z
dc.date.created1999-06
dc.identifier.issnISSN: 0049-0172
dc.identifier.issnEISSN: 1532-866X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28419
dc.description.abstractPrimary Sjögren's syndrome (SS) is an autoimmune exocrine disease characterized by salivary and lacrimal gland destruction progressing to xerostomia and xerophthalmia (sicca symptoms). Nevertheless, any exocrine as well as nonexocrine organ may be involved. Dryness is not solely a result of glandular destruction; cytokines, autoantibodies, and other soluble factors may be also involved. We propose a two-stage model of SS pathogenesis in which the initial process seems to be increased epithelial cell apoptosis leading to autoantibody production and subsequent salivary gland lymphocytic infiltration. Treatment of SS includes education, prevention, tears and saliva substitution, exocrine glands stimulation, and immunointervention. Pilocarpine, a natural alkaloid and stimulator of muscarinic receptors in exocrine glands, is an effective agent for the treatment of sicca symptoms. Another systemic stimulatory agent to treat sicca symptoms is cevimeline, a quinuclidine derivative of acetylcholine that exhibits high affinity for the muscarinic M3 receptor which is located on lacrimal and salivary gland epithelium. Molecular understanding of the biological mechanisms that lead to tissue damage in SS may lead to newer biological treatment for this common, disabling and at times devastating illness.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofSeminars in Arthritis and Rheumatism, ISSN: 0049-0172;EISSN: 1532-866X, Vol. 28, No. 6 (June 1999); pp. 355-359
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0049017299800018
dc.sourceSeminars in Arthritis and Rheumatism
dc.titleSjögren's syndrome comes of age
dc.typearticle
dc.publisherElsevier
dc.subject.keywordSjögren's syndrome
dc.subject.keywordAutoimmunity
dc.subject.keywordApoptosis
dc.subject.keywordMuscarinic receptors
dc.subject.keywordPilocarpine
dc.subject.keywordCerimeline
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.type.spaArtículo
dc.rights.accesoRestringido (Acceso a grupos específicos)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/S0049-0172(99)80001-8
dc.title.TranslatedTitleEl síndrome de Sjögren alcanza la mayoría de edad
dc.relation.citationEndPage359
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage355
dc.relation.citationTitleSeminars in Arthritis and Rheumatism
dc.relation.citationVolumeVol. 28
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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