Show simple item record

dc.creatorCruz Tapias, Paola 
dc.creatorAgmon Levin, Nancy 
dc.creatorIsraeli, Eitan 
dc.creatorAnaya, Juan-Manuel 
dc.creatorShoenfeld, Yehuda
dc.identifier.issnISSN : 0929-8673
dc.description.abstractASIA syndrome, “Autoimmune (Auto-inflammatory) Syndromes Induced by Adjuvants” includes at least four conditions which share a similar complex of signs and symptoms and have been defined by hyperactive immune responses: siliconosis, macrophagic myofasciitis syndrome, Gulf war syndrome and post-vaccination phenomena. Exposure to adjuvants has been documented in these four medical conditions, suggesting that the common denominator to these syndromes is a trigger entailing adjuvant activity. An important role of animal models in proving the ASIA concept has been established. Experimentally animal models of autoimmune diseases induced by adjuvants are currently widely used to understand the mechanisms and etiology and pathogenesis of these diseases and might thus promote the development of new diagnostic, predictive and therapeutic methods. In the current review we wish to unveil the variety of ASIA animal models associated with systemic and organ specific autoimmune diseases induced by adjuvants. We included in this review animal models for rheumatoid arthritis-like disease, for systemic lupus erythematosus-like disease, autoimmune thyroid disease-like disease, antiphospholipid syndrome, myocarditis and others. All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants.
dc.relation.ispartofAutoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants (ASIA) – Animal Models as a Proof of Concept, ISSN : 0929-8673, Vol. 20, No. 32 (2013); pp. 4030-4036
dc.sourceCurrent Medicinal Chemistry
dc.titleAutoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA)--animal models as a proof of concept
dc.subject.keywordAutoimmune syndrome
dc.subject.keywordAnimal models
dc.subject.keywordAutoinflammatory syndrome
dc.rights.accesoBloqueado (Texto referencial)
dc.title.TranslatedTitleSíndrome autoinmune (autoinflamatorio) inducido por adyuvantes (ASIA): modelos animales como prueba de concepto
dc.relation.citationIssueNo. 32
dc.relation.citationTitleCurrent Medicinal Chemistry
dc.relation.citationVolumeVol. 20

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record