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dc.creatorRamirez-Santana, Carolina 
dc.creatorPérez-Cano, F. J. 
dc.creatorCastell, M. 
dc.creatorCastellote, C. 
dc.creatorFranch, A. 
dc.date.accessioned2020-08-28T15:48:17Z
dc.date.available2020-08-28T15:48:17Z
dc.date.created2008-05-12
dc.identifier.issnISSN: 0029-6651
dc.identifier.issnEISSN: 1475-2719
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/28477
dc.description.abstractCis-9, trans-11 (c9, t11) and trans-10, cis-12 (t10, c12) are the predominating molecules in the positional and geometrical isomers mixture termed CLA. Although CLA has shown positive effects on human health and seems to be associated with immunomodulatory activities, its effect in the developing immune system has not been studied. Thus, the present study was designed to establish the effect of CLA supplementation during gestation and/or lactation on humoral immune response, i.e. by analysing sera Ig levels during the suckling period. Wistar rats were allocated to four groups (A, B, C and W) on day 7 of pregnancy. From day 7 and throughout the study period group C and W gestating mothers were fed standard pellet chow. Group A and B dams were fed 10 g CLA (80% cis-9, trans-11, 20% trans-10, cis-12; Lipid Nutrition B. V. Wormerveer, The Netherlands)/kg pellet chow during gestation. Moreover, group A mothers were also fed the CLA-supplemented chow until the litters were 21 d old, the end of suckling period. Group B and C litters received the CLA mixture of isomers by daily oral administration while their respective dams were fed standard pellet chow during lactation. In all cases litters were equalised to ten rats per lactating mother. Pups from each experimental group were killed at the end of the second week of life (day 14) and at the end of the suckling period (day 21), and blood samples were collected. Serum IgA, IgG and IgM levels were quantified by the ELISA sandwich technique. ANOVA and post hoc comparisons (LSD test) were performed. Differences were considered to be significant at P<0.05. Animals receiving CLA passively from their mothers (group A) during gestation and the suckling period exhibited the highest concentrations of IgG and IgM at 14 d old (P<0.05; see Table). At the end of suckling period the serum IgG concentration in this group was also increased, up to three times more than in the other groups (P<0.05). Those animals supplemented with CLA only during suckling period (group C) showed no difference in relation to those receiving no supplement. Thus, these results demonstrate that CLA supplementation during gestation and lactation promotes systemic humoral immune response.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofProceedings of the Nutrition Society, ISSN: 0029-6651;EISSN: 1475-2719, Vol. 67, No. OCE1 (2008); pp.E22
dc.relation.ispartof1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain
dc.relation.urihttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/96E1C9B4D9DFF9F92971314456B15EAD/S0029665108006319a.pdf/potentiation_of_systemic_humoral_immune_response_in_suckling_rats_by_conjugated_linoleic_acid_cla.pdf
dc.sourceProceedings of the Nutrition Society
dc.source1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain
dc.titlePotentiation of systemic humoral immune response in suckling rats by conjugated linoleic acid (CLA)
dc.typearticle
dc.publisherThe Nutrition Society
dc.publisherCambridge University Press
dc.subject.keywordHuman health
dc.subject.keywordHumoral inmune responde
dc.subject.keywordCLA
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1017/S0029665108006319
dc.title.TranslatedTitlePotenciación de la respuesta inmune humoral sistémica en ratas lactantes por el ácido linoleico conjugado (CLA)
dc.relation.citationIssueNo. OCE1
dc.relation.citationStartPageE22
dc.relation.citationTitleProceedings of the Nutrition Society;1st International Immunonutrition Workshop, Valencia, 3–5 October 2007, Valencia, Spain
dc.relation.citationVolumeVol. 67
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR


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