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dc.contributor.advisorHernández Herrera, Gilma Norela 
dc.creatorPortilla Pinzón, Alfredo 
dc.creatorMuñoz Claros, Conny Stefanny 
dc.creatorCastro Becerra, Ricardo 
dc.creatorGuatava Redondo, Lina Fernanda 
dc.date.accessioned2021-02-19T20:54:24Z
dc.date.available2021-02-19T20:54:24Z
dc.date.created2021-01-30
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/30951
dc.descriptionIntroducción: En los últimos años los IBP han suscitado importante interés en la literatura médica por sus efectos adversos. Sin embargo, estudios observacionales disponibles, no permiten emitir una conclusión definitiva sobre su asociación con prescripción de medicamentos para el abordaje de la osteoporosis. Objetivo: Determinar la asociación entre la exposición prolongada a IBP y la prescripción de medicamentos para el tratamiento de la osteoporosis, ajustando por variables sociodemográficas, clínicas, y farmacológicas, en pacientes asegurados al sistema de salud colombiano entre 2013 y 2018. Materiales y métodos: Estudio con enfoque cuantitativo y diseño observacional analítico de cohorte, con recolección retrospectiva de la información. Se realizo regresión logística ajustada y análisis de supervivencia para estimar la asociación y tiempo al evento, respectivamente. Resultados: La exposición prolongada a IBP (OR 1.103 IC95% 0.483-2.52) y exposición a otros medicamentos que generan osteoporosis (OR 3.724 IC95% 0.852-16.28) no fueron estadísticamente significativas (p>0.05). Por tanto, el modelo logístico final se ajustó por la edad (OR 1.06 IC95% 1.03-1.084), comorbilidad (OR 3.34 IC95% 1.27-8.81) y sexo (OR 12.82 IC95% 3.05-53.94) (p<0.05), donde el riesgo es mayor en las mujeres y es directamente proporcional a la edad. El tiempo mediano para ser formulado con algún medicamento para la osteoporosis en exposición prolongada a IBP fue de aproximadamente 22 meses (IC95% 0.345-0.683). Conclusiones: Se encontró que la exposición prolongada a IBP no está asociada con la prescripción de medicamentos para el tratamiento de la osteoporosis; sin embargo, se requieren mayores estudios para descartarla y de una prescripción responsable con evaluación de variables de riesgo y beneficio.
dc.description.abstractBackground: In the past years the proton pump inhibitors have raised a paramount interest in the medical literature due to its adverse events; however, available observational studies do not allow to conclude if they are associated with the prescription of drugs to treat osteoporosis. Study Objective: To determine the association between proton pump inhibitors' long-term exposure and the prescription of osteoporosis drug treatment, adjusting by sociodemographic, clinical and pharmacological variables, in adult patients in Colombia between 2013 and 2018. Methods: A quantitative cohort observational study with retrospective recollection of the information. Conditional logistic regression and survival analysis were applied to estimate the association and to determine the time to the event, respectively. Results: The long-term exposure (OR 1.103 CI95% 0.483-2.52) and the exposure to other drugs with potential outcome as osteoporosis (OR 3.724 CI% 0.852-16.28) were not statistically significant (p>0.05); therefore, the final logistic model was adjusted by age (OR 1.06 CI95% 1.03-1.084), comorbidities (OR 3.34 CI95% 1.27-8.81) and sex (OR 12.82 CI95% 3.05-53.94) (p<0.05), in which the risk was greater in women and directly related to the age. The median time to be prescribed with any drug to treat osteoporosis due to proton pump inhibitors' long-term exposure was approximately 22 months (CI95% 0.345-0.683). Conclusions: It was found that the long-term exposure is not associated with the prescription of osteoporosis drug treatment; nonetheless, further studies are needed to ensure the outcome. A responsible formulation of drugs by the medical team is critical, considering risk and benefit for each patient.
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.rightsAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectFármacos inhibidores de la bomba de protones (IBP)
dc.subjectCorrelación exposición prolongada a IBP y osteoporosis
dc.subjectUso de Bifosfonatos o Difosfonatos
dc.subjectUso de Denosumab
dc.subjectUso de Teriparatida
dc.subject.ddcFarmacología & terapéutica 
dc.titleAsociación entre la exposición prolongada a inhibidores de la bomba de protones y la prescripción de medicamentos para el abordaje de la osteoporosis en pacientes adultos asegurados al sistema de salud colombiano
dc.typemasterThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeMagíster en epidemiología
dc.publisher.programMaestría en Epidemiología
dc.publisher.departmentEscuela de Medicina y Ciencias de la Salud
dc.subject.keywordProton pump inhibitor (PPI) drugs
dc.subject.keywordCorrelation of prolonged exposure to PPI and osteoporosis
dc.subject.keywordUse of Bisphosphonates or Diphosphonates
dc.subject.keywordUse of Denosumab
dc.subject.keywordUse of Teriparatide
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaTesis de maestría
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
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dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.
dc.type.documentRevisión de la literatura
dc.creator.degreetypeFull time
dc.title.TranslatedTitleAssociation between proton pump inhibitors' long-term exposure and the prescription of osteoporosis drug treatment in adult patients in Colombia


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Atribución-NoComercial-SinDerivadas 2.5 Colombia
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 2.5 Colombia