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dc.contributor.advisorVillabona Luna, Rafael 
dc.contributor.advisorBeltrán Rodríguez, Johnny Adalber 
dc.contributor.advisorBecerra, Antonio 
dc.creatorGómez Gualdrón, Sergio Roldan 
dc.creatorRincon Riano, Diana Nathalie 
dc.date.accessioned2012-07-23T14:14:30Z
dc.date.available2012-07-23T14:14:30Z
dc.date.created2012-07-17
dc.date.issued2012
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/3624
dc.descriptionLa concentración de ácido láctico en LCR en pacientes con sospecha de meningitis postquirúrgica luego de clipaje de aneurisma cerebral y hemorragia subaracnoidea espontánea se midió prospectivamente por un período de tres años. Se analizaron un total de 32 muestras de líquido cefalorraquídeo, se midió la concentración de ácido láctico y se comparó con el cultivo de LCR. Los cultivos fueron positivos en cinco pacientes, con una prevalencia de infección del 15%. Se utilizó un valor umbral de ácido láctico de 4 mmol/L. y se encontró una sensibilidad del 80%, especificidad del 52%, VPP del 23%, VPN del 93%, y likelihood ratio (LHR) positivo de 1,66 con una probabilidad post test de 15% de la concentración del ácido láctico en el diagnóstico de meningitis postquirúrgica en pacientes con hemorragia subaracnoidea aneurismática. La concentración de ácido láctico en LCR tiene un desempeño limitado en el diagnóstico de meningitis postquirúrgica en pacientes con hemorragia subaracnoidea aneurismática.
dc.description.abstractThe lactic acid concentration in cerebrospinal fluid (CSF) was measured in patients with suspected meningitis after aneurysmal clipaje for spontaneous subarachnoid hemorraghe. It was measured in a prospective way during a three years period time. In total were analyzed 32 samples of CSF, the lactic acid concentration was compared against culture of CSF. The CSF culture was positive in 5 patients, with a meningitis prevalence of 15%. We use a cut-off value of 4 mmol/L for lactic acid and we find a sensitivity of 80%, specificity of 52%, VPP of 23%, VPN of 93% and a positive LHR of 1.66 with a posttest probability of 15% for the lactic acid concentration in CSF for the diagnosis of meningitis in patients with aneurysmal clipaje and subarachnoid hemorrhage. The acid lactic concentration in CSF has a limited diagnostic efficacy in patients with subarachnoid hemorrhage and suspected postquirurgical meningitis.
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dc.language.isospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subjectLíquido cefalorraquídeo
dc.subjectÁcido láctico
dc.subjectMeningitis
dc.subjectHemorragia subaracnoidea
dc.subject.lembÁcido láctico
dc.subject.lembMeningitis
dc.subject.lembEnfermedades del sistema nervioso central
dc.titleEficacia diagnostica del ácido láctico en liquido cefalorraquídeo en meningitis postclipaje de aneurisma cerebral y hemorragia subaracnoidea
dc.typebachelorThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeEspecialista en Neurocirugía
dc.publisher.programEspecialización en Neurología
dc.publisher.departmentFacultad de Medicina
dc.subject.keywordcerebrospinal fluid
dc.subject.keywordlactic acid
dc.subject.keywordmeningitis
dc.subject.keywordsubarachnoid hemorrhage
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaTrabajo de grado
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
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dc.rights.ccAtribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARÁGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización


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