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dc.creatorArias Buitrago, Juan Manuel 
dc.creatorRodríguez Ospina, Juan Carlos 
dc.date.accessioned2013-08-21T13:14:31Z
dc.date.available2013-08-21T13:14:31Z
dc.date.created2013-08-13
dc.date.issued2013
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/4629
dc.descriptionEl dolor oncológico representa una de las principales causas de dolor crónico, siendo los opioides la primera línea de manejo, sin embargo 10% de los pacientes requieren estrategias analgésicas multimodales. La eficacia analgésica de la clonidina como coadyuvante ha sido demostrada para diversos modelos de dolor. Sin embargo no hay revisiones sistemáticas que validen su eficacia y seguridad en dolor crónico oncológico. Se realizó una revisión sistemática de la literatura a noviembre 26 de 2012, encontrando 15 trabajos (12 reportes de caso y tres ensayos clínicos controlados), n=138 pacientes. La intervención tuvo una eficacia entre 44,7 y 100%, mostrando mayor beneficio en pacientes con componente de dolor neuropático. La adición de clonidina fue bien tolerada, siendo la sedación y la disminución en tensión arterial y frecuencia cardiaca los efectos secundarios más frecuentes, con relación dosis dependiente, de resolución espontánea y en ninguno de los casos se documentó lesión secundaria en los pacientes. La vía de administración más frecuente fue neuroaxial (intratecal y peridural). La revisión sistemática no fue susceptible de metaanálisis por la heterogeneidad clínica de los estudios. Los resultados obtenidos sugieren que la adición de clonidina puede ser una opción terapeútica eficaz y segura en los pacientes con dolor crónico oncológico severo refractario a opioides a altas dosis asociado o no a infusión neuroaxial de anestésico local, en especial en presencia de componente neuropático. Sin embargo se identificó la necesidad de un mayor número de ensayos clínicos controlados aleatorios que permitan establecer conclusiones definitivas.
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dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subjectDolor crónico
dc.subjectClonidina
dc.subjectNeoplasia
dc.subject.lembAnestesiología::Investigaciones
dc.subject.lembOncología::Investigaciones
dc.titleClonidina para el Tratamiento del Dolor Oncológico: una Revisión Sistemática de la Literatura
dc.typemasterThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeEspecialista en Anestesiología FCI
dc.publisher.programEspecialización en Anestesiología FCI
dc.publisher.departmentFacultad de Medicina
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsCLONIDINA - ADMINISTRACIÓN & DOSIFICACIÓN
dc.subject.decsCLONIDINA - USO TERAPÉUTICO
dc.subject.decsDOLOR CRÓNICO - TRATAMIENTO
dc.type.spaTrabajo de grado
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
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