Relación entre el polimorfismo Hind III de la lipoproteinlipasa y lípidos sanguíneos en un grupo de pacientes colombianos con enfermedad obstructiva coronaria

Abstract

HindIII polymorphism is the most common variant in the lipoprotein lipase gene, however, its association with cardiovascular disease is controversial. Objective: To establish the frequency of the HindIII polymorphism and its relationship with lipid profile and coronary arterial disease (CAD) in Colombian patients. Materials and Methods: The sample comprised patients attending a central hemodynamics of Quindio, by necessity of coronary angiography. HindIII polymorphism was evaluated by polymerase chain reaction and enzyme restriction. Results: 389 patients were divided into individuals with CAD ≥ 50% (60.4%) and individuals with EOC <50% (39.6%). Low density lipoproteins cholesterol (LDL-C) was normal, but significantly higher in CAD ≥ 50%. High density lipoprotein cholesterol (HDL-C) was low in both groups. Hind+/+ genotype and Hind+ allele frequency were 55% and 76%, respectively; for Hind+/- genotype was 41.1%, and for Hind-/- genotype and Hind- allele was 3.85% and 24%, respectively, without significant differences between groups. In CAD ≥ 50%, total cholesterol (TC) and LDL-C were higher in allele Hind-, while HDL-C was lower in the Hind+ allele, with significant differences regarding CAD <50% and the same alleles. There were significant differences in triglyceride and very low density lipoprotein cholesterol) (VLDL-C) between genotypes in CAD <50% group. Conclusion: This work shows that even with a normal lipid profile, this population presents coronary obstructive disease, which does not seem to be associated with low levels of HDL-C or the LPL HindIII polymorphism alone, but may be related to the influence of these on lipids.