Identidad Institucional CRAI
Logo EdocUR
    • English
    • español
    • português
  •  Work Submission
  •  FAQs
  • English 
    • English
    • español
    • português
  • Login

Contacto

Twitter

Facebook

Youtube

View Item 
  •   Repositorio Institucional EdocUR - Universidad del Rosario
  • Investigación
  • Artículos
  • View Item
  •   Repositorio Institucional EdocUR - Universidad del Rosario
  • Investigación
  • Artículos
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Functional Upregulation of Ca2+ -Activated K+ Channels in the Development of Substantia Nigra Dopamine Neurons

  • Exportar citas ▼
    • Exportar a Mendeley
    • Exportar a BibTex
Thumbnail
Date
2012-12
Author
Ramírez-Latorre, José
Share
Citation
URI

http://repository.urosario.edu.co/handle/10336/8766

Abstract
Many connections in the basal ganglia are made around birth when animals are exposed to a host of new affective, cognitive, and sensori-motor stimuli. It is thought that dopamine modulates cortico-striatal synapses that result in the strengthening of those connections that lead to desired outcomes. We propose that there must be a time before which stimuli cannot be processed into functional connections, otherwise it would imply an effective link between stimulus, response, and reward in uterus. Consistent with these ideas, we present evidence that early in development dopamine neurons are electrically immature and do not produce high-frequency firing in response to salient stimuli. We ask first, what makes dopamine neurons immature? and second, what are the implications of this immaturity for the basal ganglia? As an answer to the first question, we find that at birth the outward current is small (3nS-V), insensitive to Ca2z, TEA, BK, and SK blockers. Rapidly after birth, the outward current increases to 15nS-V and becomes sensitive to Ca2z, TEA, BK, and SK blockers. We make a detailed analysis of the kinetics of the components of the outward currents and produce a model for BK and SK channels that we use to reproduce the outward current, and to infer the geometrical arrangement of BK and Ca2z channels in clusters. In the first cluster, T-type Ca2z and BK channels are coupled within distances of *20 nm (200 A˚). The second cluster consists of L-type Ca2z and BK channels that are spread over distances of at least 60 nm. As for the second question, we propose that early in development, the mechanism of action selection is in a ‘‘locked-in’’ state that would prevent dopamine neurons from reinforcing cortico-striatal synapses that do not have a functional experiential- based value.

Subject

Enfermedades ;

Source link

http://www.ncbi.nlm.nih.gov.ez.urosario.edu.co/pmc/articles/PMC3527479/pdf/pone....

Show full item record

Collections
  • Artículos [6079]
Política de Acceso Abierto URPortal de Revistas URRepositorio de Datos de Investigación URCiencia Abierta UR
 

 

Browse

All of DSpaceCommunities & CollectionsTitlesAuthorsTypeSubjectsAdvisorBy Issue DateThis CollectionTitlesAuthorsTypeSubjectsAdvisorBy Issue Date

My Account

LoginRegister

Statistics

View Usage Statistics
Política de Acceso Abierto URPortal de Revistas URRepositorio de Datos de Investigación URCiencia Abierta UR