Systemic Lupus Erythematosus 2014
Date
2014Share
Citation
Abstract
Systemic lupus erythematosus (SLE, lupus) is the prototype
of systemic autoimmune disease (AD). Immune system
activation in SLE is characterized by exaggerated B-cell and
T-cell responses and loss of immune tolerance against selfantigens.
Production and defective elimination of antibodies,
circulation and tissue deposition of immune complexes, and
complement and cytokine activation contribute to clinical
manifestations that range from fatigue and joint pain to
severe, life-threatening organ damage
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