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dc.creatorCruz-Tapias, Paola 
dc.creatorPerez-Fernandez, Oscar-Mauricio 
dc.creatorRojas-Villarraga, Adriana 
dc.creatorRodríguez-Rodríguez, Alberto 
dc.creatorArango, María-Teresa 
dc.creatorAnaya, Juan-Manuel 
dc.date.accessioned2014-08-11T19:11:45Z
dc.date.available2014-08-11T19:11:45Z
dc.date.created2012-10-15
dc.date.issued2012
dc.identifier.issnISSN:2090-0430
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8775
dc.description.abstractThe prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1∗03:01 (OR: 4.04; 95%CI: 1.41–11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren’s syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1 ¨ ∗04:05 (OR: 4.64; 95%CI: 2.14–10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1∗04:01 (OR: 3.86; 95%CI: 2.32–6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1∗06:02 and DRB1∗15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1∗06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofAutoimmune Diseases, ISSN 2090-04-30, 2012
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedades 
dc.titleShared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsHepatitis autoinmune
dc.subject.decsArtritis reumatoide
dc.subject.decsEsclerosis múltiple
dc.subject.decsInmunología
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumento
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleCruz-Tapias, Paola
dc.creator.googlePerez-Fernandez, Oscar-Mauricio
dc.creator.googleRojas-Villarraga, Adriana
dc.creator.googleRodríguez-Rodríguez, Alberto
dc.creator.googleArango, María-Teresa
dc.creator.googleAnaya, Juan-Manuel
dc.relation.citationTitleAutoimmune Diseases


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