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dc.creatorPatarroyo, Manuel E. 
dc.creatorPatricia Alba, Martha 
dc.creatorCurtidor, Hernando 
dc.creatorVanegas, Magnolia 
dc.creatorAlmonacid, Hannia 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2014-08-12T16:23:29Z
dc.date.available2014-08-12T16:23:29Z
dc.date.created2014-02
dc.date.issued2014
dc.identifier.issnISSN:1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8808
dc.description.abstractPlasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this similar to 300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 9 N. 2 Feb 7, 2014
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088420
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedades 
dc.titleUsing the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordERYTHROCYTE-MEMBRANE PROTEIN-1
dc.subject.keywordCHONDROITIN-SULFATE-A
dc.subject.keywordPLASMODIUM-FALCIPARUM
dc.subject.keywordANTIMALARIAL VACCINE
dc.subject.keywordPLACENTAL MALARIA
dc.subject.keywordALPHA-DOMAINS
dc.subject.keywordEXPRESSION
dc.subject.keywordANTIBODIES
dc.subject.keywordPARASITES
dc.subject.keywordPEPTIDES
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsPlasmodium
dc.subject.decsMalaria
dc.subject.decsInmunología
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumento
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googlePatarroyo, Manuel E.
dc.creator.googlePatricia Alba, Martha
dc.creator.googleCurtidor, Hernando
dc.creator.googleVanegas, Magnolia
dc.creator.googleAlmonacid, Hannia
dc.creator.googlePatarroyo, Manuel A.
dc.relation.citationIssueNo. 2
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 9


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