dc.creator | Patarroyo, Manuel E. |
dc.creator | Patricia Alba, Martha |
dc.creator | Curtidor, Hernando |
dc.creator | Vanegas, Magnolia |
dc.creator | Almonacid, Hannia |
dc.creator | Patarroyo, Manuel A. |
dc.date.accessioned | 2014-08-12T16:23:29Z |
dc.date.available | 2014-08-12T16:23:29Z |
dc.date.created | 2014-02 |
dc.date.issued | 2014 |
dc.identifier.issn | ISSN:1932-6203 |
dc.identifier.uri | http://repository.urosario.edu.co/handle/10336/8808 |
dc.description.abstract | Plasmodium falciparum (Pf) malaria causes 200 million cases worldwide, 8 million being severe and complicated leading to similar to 1 million deaths and similar to 100,000 abortions annually. Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) has been implicated in cytoadherence and infected erythrocyte rosette formation, associated with cerebral malaria; chondroitin sulphate-A attachment and infected erythrocyte sequestration related to pregnancy-associated malaria and other severe forms of disease. An endothelial cell high activity binding peptide is described in several of this similar to 300 kDa hypervariable protein's domains displaying a conserved motif (GACxPxRRxxLC); it established H-bonds with other binding peptides to mediate red blood cell group A and chondroitin sulphate attachment. This motif (when properly modified) induced PfEMP1-specific strain-transcending, fully-protective immunity for the first time in experimental challenge in Aotus monkeys, opening the way forward for a long sought-after vaccine against severe malaria. |
dc.format.medium | Recurso electrónico |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.relation.ispartof | PLOS ONE ISSN: 1932-6203 V. 9 N. 2 Feb 7, 2014 |
dc.relation.uri | http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088420 |
dc.source | instname:Universidad del Rosario |
dc.source | reponame:Repositorio Institucional EdocUR |
dc.subject.ddc | Enfermedades |
dc.title | Using the PfEMP1 Head Structure Binding Motif to Deal a Blow at Severe Malaria |
dc.type | article |
dc.audience | Comunidad Rosarista |
dc.publisher | Universidad del Rosario |
dc.subject.keyword | ERYTHROCYTE-MEMBRANE PROTEIN-1 |
dc.subject.keyword | CHONDROITIN-SULFATE-A |
dc.subject.keyword | PLASMODIUM-FALCIPARUM |
dc.subject.keyword | ANTIMALARIAL VACCINE |
dc.subject.keyword | PLACENTAL MALARIA |
dc.subject.keyword | ALPHA-DOMAINS |
dc.subject.keyword | EXPRESSION |
dc.subject.keyword | ANTIBODIES |
dc.subject.keyword | PARASITES |
dc.subject.keyword | PEPTIDES |
dc.rights.accesRights | info:eu-repo/semantics/openAccess |
dc.subject.decs | Plasmodium |
dc.subject.decs | Malaria |
dc.subject.decs | Inmunología |
dc.type.spa | Artículo |
dc.rights.acceso | Abierto (Texto completo) |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion |
dc.format.tipo | Documento |
dc.rights.licencia | EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. |
dc.creator.google | Patarroyo, Manuel E. |
dc.creator.google | Patricia Alba, Martha |
dc.creator.google | Curtidor, Hernando |
dc.creator.google | Vanegas, Magnolia |
dc.creator.google | Almonacid, Hannia |
dc.creator.google | Patarroyo, Manuel A. |