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dc.creatorRojas-Villarraga, Adriana 
dc.creatorAmaya-Amaya, Jenny-Carolina 
dc.creatorRodriguez-Rodriguez, Alberto 
dc.creatorMantilla, Rubén D. 
dc.creatorAnaya, Juan-Manuel 
dc.description.abstractSimilar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjögren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006–September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.
dc.format.mediumRecurso electrónico
dc.relation.ispartofAutoimmune Diseases, ISSN 2090-04-30, 2012
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subject.ddcIncidencia & prevención de la enfermedad 
dc.titleIntroducing polyautoimmunity: secondary autoimmune diseases no longer exist
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.decsEnfermedades autoinmunes
dc.rights.accesoAbierto (Texto completo)
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleRojas-Villarraga, Adriana
dc.creator.googleAmaya-Amaya, Jenny
dc.creator.googleRodriguez-Rodriguez, Alberto
dc.creator.googleMantilla, Rubén D.
dc.creator.googleAnaya, Juan-Manuel

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