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dc.creatorHerrera-Díaz, Ana-Catalina 
dc.creatorZubiria Salgado, Alberto de 
dc.description.abstractLupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. In susceptible individuals suffering of SLE, in situ formation and deposit of immune complexes (ICs) from apoptotic bodies occur in the kidneys as a result of an amplified epitope immunological response. IC glomerular deposits generate release of proinflammatory cytokines and cell adhesion molecules causing inflammation. This leads to monocytes and polymorphonuclear cells chemotaxis. Subsequent release of proteases generates endothelial injury and mesangial proliferation. Presence of ICs promotes adaptive immune response and causes dendritic cells to release type I interferon. This induces maturation and activation of infiltrating T cells, and amplification of Th2, Th1 and Th17 lymphocytes. Each of them, amplify B cells and activates macrophages to release more proinflammatory molecules, generating effector cells that cannot be modulated promoting kidney epithelial proliferation and fibrosis. Herein immunopathological findings of LN are reviewed.
dc.format.mediumRecurso electrónico
dc.relation.ispartofAutoimmune Diseases, ISSN 2090-04-30, 2012
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleLupus nephritis: an overview of recent findings
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.decsNefritis lúpica
dc.subject.decsEnfermedades de los riñones
dc.subject.decsCélulas dendríticas
dc.subject.decsLupus eritematoso sistémico
dc.rights.accesoAbierto (Texto completo)
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleHerrera-Díaz, Ana-Catalina
dc.creator.googleZubiria Salgado, Alberto de

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