Acceso Abierto

Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis

Título de la revista
Barragán Martínez, Carolina
Speck Hernández, Cesar A.
Montoya-Ortiz, Gladis
Mantilla, Rubén D.
Anaya, Juan-Manuel
Rojas-Villarraga, Adriana



ISSN de la revista
Título del volumen
Universidad del Rosario


Métricas alternativas

Background: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value, 0.001). Conclusion: Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.
Palabras clave
Cirrosis biliar primaria , Aductos de proteína de aldehído , Activación de células T , Autoinmunidad mediada , Tricloroeteno , Exposición al cloruro de vinilo , Esclerosis múltiple , Exposicion ocupacional , Lupus eritematoso , Factores medioambientales , Enfermeras anestesistas
Primary biliary cirrhosis , Aldehyde-protein adducts , T-cell-activation , Trichloroethene-mediated autoimmunity , Vinyl-chloride exposure , Multiple-sclerosis , Occupational-exposure , Lupus-erythematosus , Environmental-factors , Nurse anesthetists