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dc.creatorBarragán Martínez, Carolina 
dc.creatorSpeck Hernández, Cesar A. 
dc.creatorMontoya-Ortiz, Gladis 
dc.creatorMantilla, Rubén D. 
dc.creatorAnaya, Juan-Manuel 
dc.creatorRojas-Villarraga, Adriana 
dc.date.accessioned2014-08-13T16:19:59Z
dc.date.available2014-08-13T16:19:59Z
dc.date.created2012-12
dc.date.issued2012
dc.identifier.issnISSN:1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8830
dc.description.abstractBackground: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value, 0.001). Conclusion: Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 7 N. 12 Dic, 2012
dc.relation.urihttp://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0051506&representation=PDF
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subject.ddcEvolución & genética 
dc.titleOrganic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordPRIMARY BILIARY CIRRHOSIS
dc.subject.keywordALDEHYDE-PROTEIN ADDUCTS
dc.subject.keywordT-CELL-ACTIVATION
dc.subject.keywordTRICHLOROETHENE-MEDIATED AUTOIMMUNITY
dc.subject.keywordVINYL-CHLORIDE EXPOSURE
dc.subject.keywordMULTIPLE-SCLEROSIS
dc.subject.keywordOCCUPATIONAL-EXPOSURE
dc.subject.keywordLUPUS-ERYTHEMATOSUS
dc.subject.keywordENVIRONMENTAL-FACTORS
dc.subject.keywordNURSE ANESTHETISTS
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsGenética
dc.subject.decsRepresión epigenética
dc.subject.decsEnfermedades autoinmunes
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumento
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleBarragán Martínez, Carolina
dc.creator.googleSpeck Hernández, Cesar A.
dc.creator.googleMontoya-Ortiz, Gladis
dc.creator.googleMantilla, Rubén D.
dc.creator.googleAnaya, Juan-Manuel
dc.creator.googleRojas-Villarraga, Adriana
dc.relation.citationIssueNo. 12
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 7


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