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dc.creatorGarzón Ospina, Diego 
dc.creatorLopez, Carolina 
dc.creatorForero Rodriguez, Johanna 
dc.creatorPatarroyo, Manuel A. 
dc.date.accessioned2014-08-13T16:26:14Z
dc.date.available2014-08-13T16:26:14Z
dc.date.created2012-09-25
dc.date.issued2012
dc.identifier.issnISSN:1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8831
dc.description.abstractA completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 7 N. 9 Sep. 25, 2012
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0045962
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedades 
dc.titleGenetic diversity and selection in three plasmodium vivax merozoite surface protein 7 (pvmsp-7) genes in a colombian population
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordCAENORHABDITIS-ELEGANS GENOME
dc.subject.keywordAMINO-ACID SITES
dc.subject.keywordMALARIA PARASITE
dc.subject.keywordPOSITIVE SELECTION
dc.subject.keywordINTRAGENIC RECOMBINATION
dc.subject.keywordSTATISTICAL TESTS
dc.subject.keywordDEATH EVOLUTION
dc.subject.keywordMSP7 FAMILY
dc.subject.keywordFALCIPARUM
dc.subject.keywordCOMPLEX
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsMalaria
dc.subject.decsGenoma
dc.subject.decsEnfermedades infecciosas
dc.subject.decsGenética
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumento
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleGarzon Ospina, Diego
dc.creator.googleLopez, Carolina
dc.creator.googleForero Rodriguez, Johanna
dc.creator.googlePatarroyo, Manuel A.
dc.relation.citationIssueNo. 9
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 7


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