Show simple item record

dc.creatorAnaya, Juan-Manuel 
dc.creatorDelgado Vega, Angélica María 
dc.creatorCastiblanco, John 
dc.date.accessioned2014-08-13T18:54:08Z
dc.date.available2014-08-13T18:54:08Z
dc.date.created2006
dc.date.issued2006
dc.identifier.issnISSN:1740-2522
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8836
dc.description.abstractSjögren's syndrome (SS) is a late-onset chronic autoimmune disease (AID) affecting the exocrine glands, mainly the salivary and lachrymal. Genetic studies on twins with primary SS have not been performed, and only a few case reports describing twins have been published. The prevalence of primary SS in siblings has been estimated to be 0.09% while the reported general prevalence of the disease is approximately 0.1%. The observed aggregation of AIDs in families of patients with primary SS is nevertheless supportive for a genetic component in its etiology. In the absence of chromosomal regions identified by linkage studies, research has focused on candidate gene approaches (by biological plausibility) rather than on positional approaches. Ancestral haplotype 8.1 as well as TNF, IL10 and SSA1 loci have been consistently associated with the disease although they are not specific for SS. In this review, the genetic component of SS is discussed on the basis of three known observations: (a) age at onset and sex-dependent presentation, (b) familial clustering of the disease, and (c) dissection of the genetic component. Since there is no strong evidence for a specific genetic component in SS, a large international and collaborative study would be suitable to assess the genetics of this disorder.
dc.format.mediumRecurso electrónico
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofClinical & Developmental Immunology ISSN 1740-2522 V. 13 N. 2-4 Jun, 2006
dc.relation.urihttp://web.a.ebscohost.com.ez.urosario.edu.co/ehost/pdfviewer/pdfviewer?sid=12158b70-776b-43d0-8069-ce5f294e3918%40sessionmgr4003&vid=2&hid=4101
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subject.ddcIncidencia & prevención de la enfermedad 
dc.titleGenetic basis of Sjögren's syndrome. How strong is the evidence?
dc.typearticle
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordCHRM3
dc.subject.keywordIL10
dc.subject.keywordSjögren's syndrome
dc.subject.keywordSSA1
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.subject.decsSíndrome de Sjögren
dc.subject.decsEnfermedades autoinmunes
dc.subject.decsInmunología
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.format.tipoDocumento
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleAnaya, Juan-Manuel
dc.creator.googleDelgado Vega, Angélica María
dc.creator.googleCastiblanco, John
dc.identifier.doihttps://doi.org/10.1080/17402520600876911
dc.relation.citationIssueNo. 2
dc.relation.citationTitleClinical & Developmental Immunology
dc.relation.citationVolumeVol. 13


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record