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The putative protective role of hepatitis B virus (HBV) infection from autoimmune disorders

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dc.creatorRam, Mayaspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorBarzilai, Orispa
dc.creatorIzhaky, Davidspa
dc.creatorKatz, Bat-sheva Poratspa
dc.creatorBlank, Mirispa
dc.creatorShoenfeld, Yehudaspa
dc.date.accessioned2020-05-26T00:01:22Z
dc.date.available2020-05-26T00:01:22Z
dc.date.created2008spa
dc.description.abstractBackground: The etiology of autoimmune diseases is not fully clarified and the mechanisms underlying their initiation and progression are still obscure. It is becoming clear that in a genetic susceptible individual an environmental trigger such as infectious agent in general and viruses in particular could initiate the development of an autoimmune disease. Hepatitis B virus (HBV) is notorious in its association with diverse autoimmune diseases. Therefore, we aimed to determine the presence of hepatitis B core antibody (HBcAb), a seromarker for past or present infection with HBV, in a large number of sera collected from patients with different autoimmune diseases. Methods: A cohort of 675 sera samples of 5 different autoimmune diseases and healthy donors were screened for evidence of a prior infection with HBV. All samples were tested for hepatitis B core antibody (IgG) using the Monolisa anti-HBc PLUS commercial kit (Bio-Rad, Hercules, San Francisco, USA). Results: Lower percentage of HBcAb was found in sera of the autoimmune diseases when compared to normal controls. Fifteen (10.7%) from 140 normal controls were found positive for the presence of HBcAb. Two (2%) out of 98 multiple sclerosis (MS) sera were positive for the presence of HBcAb (OR: 0.17, 95%CI: 0.03-0.77, p = 0.01), 3 (2.5%) out of 117 systemic lupus erythematosus (SLE) sera (OR: 0.2, 95%CI: 0.06-0.77, p = 0.01), 4 (4.5%) out of 89 type 1 diabetes (T1D), 5 (6.1%) from 82 Sjogren's syndrome (SS) sera and 12 (8%) from 149 rheumatoid arthritis (RA) sera were positive for the presence of HBcAb. Conclusions: Our data divulge an unexpected low percentage of antibodies to HBcAg in patients with SLE, MS and T1D in comparison to healthy matched donors. This finding may raise a protective role to HBV in some autoimmune diseases i.e. hygiene theory. © 2008 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2008.06.008
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23356
dc.language.isoengspa
dc.relation.citationEndPage625
dc.relation.citationIssueNo. 8
dc.relation.citationStartPage621
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 7
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.7, No.8 (2008); pp. 621-625spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-50949126626&doi=10.1016%2fj.autrev.2008.06.008&partnerID=40&md5=3f5a41252f3bec9c3ffb3ce8809df214spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordHepatitis B core antibodyspa
dc.subject.keywordImmunoglobulin Gspa
dc.subject.keywordAnamnesisspa
dc.subject.keywordAntibody blood levelspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordBlood samplingspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordHepatitis Bspa
dc.subject.keywordHepatitis B virusspa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordScreening testspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordHepatitis Bspa
dc.subject.keywordHepatitis B Antibodiesspa
dc.subject.keywordHepatitis B virusspa
dc.subject.keywordHumansspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordHepatitis B core antibody (hbcab)spa
dc.subject.keywordHepatitis B virus (HBV)spa
dc.subject.keywordMultiple sclerosis (MS)spa
dc.subject.keywordRheumatoid arthritis (RA)spa
dc.subject.keywordSjogren's syndrome (SS)spa
dc.subject.keywordSystemic lupus erythematosus (SLE)spa
dc.subject.keywordType 1 diabetes (T1D)spa
dc.titleThe putative protective role of hepatitis B virus (HBV) infection from autoimmune disordersspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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