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Zika virus and neurologic autoimmunity: The putative role of gangliosides

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorSalgado-Castaneda, Ignaciospa
dc.creatorChang, Christopherspa
dc.creatorAnsari, Aftabspa
dc.creatorGershwin, M. Ericspa
dc.date.accessioned2020-05-26T00:03:16Z
dc.date.available2020-05-26T00:03:16Z
dc.date.created2016spa
dc.description.abstractAn increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barré syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection. © 2016 Anaya et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12916-016-0601-y
dc.identifier.issn17417015
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23575
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Medicine
dc.relation.citationVolumeVol. 14
dc.relation.ispartofBMC Medicine, ISSN:17417015, Vol.14, No.1 (2016)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84962091501&doi=10.1186%2fs12916-016-0601-y&partnerID=40&md5=a19bc0953416ed0c71edb149723fd8a3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGangliosidespa
dc.subject.keywordGanglioside gd 1aspa
dc.subject.keywordGanglioside gd 1bspa
dc.subject.keywordGanglioside gm1spa
dc.subject.keywordGanglioside gt1spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordGangliosidespa
dc.subject.keywordArticlespa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBrain developmentspa
dc.subject.keywordFlavivirusspa
dc.subject.keywordFlavivirus infectionspa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunopathogenesisspa
dc.subject.keywordMicrocephalyspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordNerve cellspa
dc.subject.keywordNeurotropismspa
dc.subject.keywordZika virusspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBrainspa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordImmunologyspa
dc.subject.keywordMicrocephalyspa
dc.subject.keywordPathogenicityspa
dc.subject.keywordVirologyspa
dc.subject.keywordZika feverspa
dc.subject.keywordZika virusspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordBrainspa
dc.subject.keywordGangliosidesspa
dc.subject.keywordGuillain-barre syndromespa
dc.subject.keywordHumansspa
dc.subject.keywordMicrocephalyspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordZika virusspa
dc.subject.keywordZika virus infectionspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordGangliosidesspa
dc.subject.keywordGuillain-barré syndromespa
dc.subject.keywordMicrocephalyspa
dc.subject.keywordZika virusspa
dc.titleZika virus and neurologic autoimmunity: The putative role of gangliosidesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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