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Short-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in rats

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dc.creatorLee, S. H.spa
dc.creatorMastronardi, C. A.spa
dc.creatorLi, R. W.spa
dc.creatorPaz-Filho, G.spa
dc.creatorDutcher, E. G.spa
dc.creatorLewis, M. D.spa
dc.creatorVincent, A. D.spa
dc.creatorSmith, P. N.spa
dc.creatorBornstein, S. R.spa
dc.creatorLicinio, J.spa
dc.creatorWong, M. L.spa
dc.date.accessioned2020-05-26T00:01:38Z
dc.date.available2020-05-26T00:01:38Z
dc.date.created2019spa
dc.description.abstractAntidepressants are among the most-prescribed class of drugs in the world and though weight gain is a common outcome of antidepressant treatment, that effect is not well understood. We employed an animal model comprised of 2 weeks of chronic restraint stress with antidepressant treatment, followed by diet-induced obesity. We showed that short-term antidepressant treatment had long-lasting effects, not only leading to weight gain, but also enhancing trabecular and cortical bone features in rats; therefore, weight gain in this model was different from that of the classic diet-induced obesity. Late in the post-restraint recovery period, antidepressant-treated animals were significantly heavier and had better bone features than saline-treated controls, when assessed in the distal femoral metaphysis. The propensity to gain weight might have influenced the rate of catch-up growth and bone allometry, as heavier animals treated with fluoxetine also had enhanced bone features when compared to non-stressed animals. Therefore, short-term antidepressant treatment ameliorated the long-term effects of stress on body growth and bone. Growth and bone structural features were associated with leptin levels, and the interaction between leptin levels and antidepressant was significant for bone mineral content, suggesting that short-term antidepressants in the context of long-term diet-induced obesity modified the role of leptin in bone formation. To our knowledge this is the first study reporting that short-term antidepressant treatment has long-lasting effects in restoring the effects of chronic stress in body weight and bone formation. Our findings may be relevant to the understanding and treatment of osteoporosis, a condition of increasing prevalence due to the aging population. © 2019, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41398-018-0351-z
dc.identifier.issn21583188
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23390
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleTranslational Psychiatry
dc.relation.citationVolumeVol. 9
dc.relation.ispartofTranslational Psychiatry, ISSN:21583188, Vol.9, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060219068&doi=10.1038%2fs41398-018-0351-z&partnerID=40&md5=a46b517933930b84192a1fde089520a0spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordFluoxetinespa
dc.subject.keywordImipraminespa
dc.subject.keywordInsulin growth factor 1spa
dc.subject.keywordLeptinspa
dc.subject.keywordSomatomedinspa
dc.subject.keywordTriacylglycerolspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAntidepressant agentspa
dc.subject.keywordFluoxetinespa
dc.subject.keywordLeptinspa
dc.subject.keywordAllometryspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordAnxietyspa
dc.subject.keywordArticlespa
dc.subject.keywordBody weight gainspa
dc.subject.keywordBone growthspa
dc.subject.keywordBone lengthspa
dc.subject.keywordBone mineralspa
dc.subject.keywordBone structurespa
dc.subject.keywordCatch up growthspa
dc.subject.keywordChronic stressspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCortical bonespa
dc.subject.keywordDiet induced obesityspa
dc.subject.keywordDistal femurspa
dc.subject.keywordFat massspa
dc.subject.keywordFemur metaphysisspa
dc.subject.keywordFood intakespa
dc.subject.keywordImmobilization stressspa
dc.subject.keywordLean body weightspa
dc.subject.keywordLipolysisspa
dc.subject.keywordMalespa
dc.subject.keywordMrna expression levelspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOssificationspa
dc.subject.keywordRatspa
dc.subject.keywordTrabecular bonespa
dc.subject.keywordTreatment durationspa
dc.subject.keywordTriacylglycerol blood levelspa
dc.subject.keywordAnimalspa
dc.subject.keywordAnimal behaviorspa
dc.subject.keywordBody weight gainspa
dc.subject.keywordBone densityspa
dc.subject.keywordDisease modelspa
dc.subject.keywordDrug effectspa
dc.subject.keywordDrug therapyspa
dc.subject.keywordMental stressspa
dc.subject.keywordMetabolismspa
dc.subject.keywordObesityspa
dc.subject.keywordSprague dawley ratspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntidepressive agentsspa
dc.subject.keywordBehavioreng
dc.subject.keywordBone densityspa
dc.subject.keywordDisease modelseng
dc.subject.keywordFluoxetinespa
dc.subject.keywordLeptinspa
dc.subject.keywordMalespa
dc.subject.keywordObesityspa
dc.subject.keywordRatsspa
dc.subject.keywordRatseng
dc.subject.keywordStresseng
dc.subject.keywordWeight gainspa
dc.titleShort-term antidepressant treatment has long-lasting effects, and reverses stress-induced decreases in bone features in ratsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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