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Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

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dc.creatorHarris, Valerie Mspa
dc.creatorSharma, Rohanspa
dc.creatorCavett, Joshuaspa
dc.creatorKurien, Biji Tspa
dc.creatorLiu, Kespa
dc.creatorKoelsch, Kristi Aspa
dc.creatorRasmussen, Astridspa
dc.creatorRadfar, Lidaspa
dc.creatorLewis, Davidspa
dc.creatorStone, Donald Uspa
dc.creatorKaufman, C Erickspa
dc.creatorLi, Shibospa
dc.creatorSegal, Barbaraspa
dc.creatorWallace, Daniel Jspa
dc.creatorWeisman, Michael Hspa
dc.creatorVenuturupalli, Swamyspa
dc.creatorKelly, Jennifer Aspa
dc.creatorAlarcon-Riquelme, Marta Espa
dc.creatorPons-Estel, Bernardospa
dc.creatorJonsson, Rolandspa
dc.creatorLu, Xianglanspa
dc.creatorGottenberg, Jacques-Ericspa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorCunninghame-Graham, Deborah Sspa
dc.creatorHuang, Andrew J Wspa
dc.creatorBrennan, Michael Tspa
dc.creatorHughes, Pamelaspa
dc.creatorAlevizos, Iliasspa
dc.creatorMiceli-Richard, Corinnespa
dc.creatorKeystone, Edward Cspa
dc.creatorBykerk, Vivian Pspa
dc.creatorHirschfield, Gideonspa
dc.creatorXie, Gangspa
dc.creatorSiminovitch, Katherine Aspa
dc.creatorNg, Wan-Faispa
dc.creatorNordmark, Gunnelspa
dc.creatorBucher, Sara Magnussonspa
dc.creatorEriksson, Perspa
dc.creatorOmdal, Roaldspa
dc.creatorRhodus, Nelson Lspa
dc.creatorRischmueller, Maureenspa
dc.creatorRohrer, Michaelspa
dc.creatorWahren-Herlenius, Mariespa
dc.creatorWitte, Torstenspa
dc.creatorMariette, Xavierspa
dc.creatorLessard, Christopher Jspa
dc.creatorHarley, John Bspa
dc.creatorSivils, Kathy Lspa
dc.creatorScofield, R Halspa
dc.date.accessioned2020-05-26T00:04:26Z
dc.date.available2020-05-26T00:04:26Z
dc.date.created2016spa
dc.description.abstractPrimary Sjögren's syndrome (pSS) has a strong female bias. We evaluated an X chromosome dose effect by analyzing 47,XXY (Klinefelter's syndrome, 1 in 500 live male births) among subjects with pSS. 47,XXY was determined by examination of fluorescence intensity of single nucleotide polymorphisms from the X and Y chromosomes. Among 136 pSS men there were 4 with 47,XXY. This was significantly different from healthy controls (1 of 1254 had 47,XXY, p = 0.0012 by Fisher's exact test) as well men with rheumatoid arthritis (0 of 363 with 47,XXY), but not different compared to men with systemic lupus erythematosus (SLE) (4 of 136 versus 8 of 306, Fisher's exact test p = NS). These results are consistent with the hypothesis that the number of X chromosomes is critical for the female bias of pSS, a property that may be shared with SLE but not RA. © 2016.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.clim.2016.04.002
dc.identifier.issn15217035
dc.identifier.issn15216616
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23684
dc.language.isoengspa
dc.publisherAcademic Press Inc.spa
dc.relation.citationEndPage29
dc.relation.citationStartPage25
dc.relation.citationTitleClinical Immunology
dc.relation.citationVolumeVol. 168
dc.relation.ispartofClinical Immunology, ISSN:15217035, 15216616, Vol.168,(2016); pp. 25-29spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84964989106&doi=10.1016%2fj.clim.2016.04.002&partnerID=40&md5=466d592950e39839956e903f74db8382spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArticlespa
dc.subject.keywordSystemiceng
dc.subject.keywordHumaneng
dc.subject.keywordSingle Nucleotideeng
dc.subject.keywordRheumatoideng
dc.subject.keywordHumaneng
dc.subject.keywordControlled studyspa
dc.subject.keywordXeng
dc.subject.keywordFluorescencespa
dc.subject.keywordYeng
dc.subject.keywordGenderspa
dc.subject.keywordHumanspa
dc.subject.keywordKlinefelter syndromespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordX chromosomespa
dc.subject.keywordY chromosomespa
dc.subject.keywordClinical trialspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordKlinefelter syndromespa
dc.subject.keywordMulticenter studyspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordArthritiseng
dc.subject.keywordChromosomeseng
dc.subject.keywordChromosomeseng
dc.subject.keywordFemalespa
dc.subject.keywordGene Frequencyspa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordKlinefelter Syndromespa
dc.subject.keywordLupus Erythematosuseng
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSjogren's Syndromespa
dc.subject.keywordKlinefelter's syndromespa
dc.subject.keywordSex biasspa
dc.subject.keywordSjögren's syndromespa
dc.subject.keywordX chromosomespa
dc.titleKlinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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