2026-04-27T00:07:32Zhttps://repository.urosario.edu.co/oai/request

oai:repository.urosario.edu.co:10336/236692022-05-02T07:37:13Zcom_10336_39998com_10336_563col_10336_683

Tobón G.J. Correa P.A. Gomez L.M. Anaya, Juan-Manuel 2020-05-26T00:04:14Z 2020-05-26T00:04:14Z 2005 Objective: To investigate the previously reported association of tumor necrosis factor alpha (TNF) -308 single nucleotide polymorphism (SNP) with the clinical course and immunological features in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Methods: The studied group consisted of 113 consecutive SLE and 65 pSS patients. TNF -308 SNP was determined by the polymerase chain reaction-restriction fragment length polymorphism technique. Clinical and immunological characteristics were assessed according to a standard protocol that included disease activity (SLEDAI) and damage (SLICC Damage Index). Serum TNF? levels were measured in samples collected from 32 patients with SLE and 16 with pSS by enzyme-linked immunosorbent assay. Results: The TNF2 allele (A) was observed in 46% and 54% of SLE and pSS patients, respectively. We failed to find any significant association between the -308 SNP and disease manifestations, the presence of autoantibodies or cytokine levels in either group. Conclusion: TNF -308 SNP (TNF2) does not exhibit a significant influence on the disease course or immunological response in SLE and pSS. Other genetic and/or environmental factors seem to be required and to be more important than TNF2 allele for the progression of these diseases. application/pdf 0392856X 1593098X https://repository.urosario.edu.co/handle/10336/23669 eng 344 No. 3 339 Clinical and Experimental Rheumatology Vol. 23 Clinical and Experimental Rheumatology, ISSN:0392856X, 1593098X, Vol.23, No.3 (2005); pp. 339-344 https://www.scopus.com/inward/record.uri?eid=2-s2.0-20444455423&partnerID=40&md5=e199285473e2eca428e16c665574e628 info:eu-repo/semantics/openAccess Abierto (Texto Completo) instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR Autoantibody Tumor necrosis factor Adult Allele Article Blood sampling Clinical feature Clinical protocol Controlled study Disease activity Disease course Environmental factor Enzyme linked immunosorbent assay Female Genetic analysis Human Immune response Immunology Major clinical study Male Polymerase chain reaction Priority journal Protein analysis Protein blood level Restriction fragment length polymorphism Single nucleotide polymorphism Sjoegren syndrome Systemic lupus erythematosus Adult Enzyme-linked immunosorbent assay Female Genetic predisposition to disease Health status Humans Male Severity of illness index Sjogren's syndrome Tumor necrosis factor-alpha Polymorphism Primary sjögren's syndrome Systemic lupus erythematosus Tumor necrosis factor systemic single nucleotide Lupus erythematosus Polymorphism Lack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjögren's syndrome article info:eu-repo/semantics/publishedVersion Artículo