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Tobon, GJ Correa, PA Gomez, LM Anaya, Juan-Manuel 2020-06-11T13:21:23Z 2020-06-11T13:21:23Z 2005 To investigate the previously reported association of tumor necrosis factor alpha (TNF) -308 single nucleotide polymorphism (SNP) with the clinical coarse and immunological features in patients with systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (pSS).Methods The studied group consisted of 113 consecutive SLE and 65 pSS patients. TNF -308 SNP was determined by the polymerase chain reactioin-restriction fragment length polymorphism technique. Clinical and immunological characteristics were assessed according to a standard protocol that included disease activity (SLEDAI) and damage (SLICC Damage Index). Serum TNF alpha levels were measared in samples collected from 32 patients with SLE and 16 with pSS by enzyme-linked immunosorbent assay.Results The TNF2 allele (A) was observed in 46% and 54% of SLE and pSS patients, respectively. We failed to find any significant association between the -308 SNP and disease manifestations, the presence of antoantibodies or cytokine levels in either group.Conclusion TNF -308 SNP (TNF2) does not exhibit a significant influence on the disease course or immunological response in SLE and pSS. Other genetic and/or environmental factors seem to be required and to be more important than TNF2 allele for the progression of these diseases. application/pdf 0392-856X 1593-098X https://repository.urosario.edu.co/handle/10336/24854 eng Pacini Editore SpA 344 No. 3 339 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY Vol. 23 CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, ISSN:0392-856X ; 1593-098X, Vol.23, No.3 (2005); pp. 339-344 info:eu-repo/semantics/closedAccess Bloqueado (Texto referencial) instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR factor de necrosis tumoral polimorfismo síndrome de Sjogren primario lupus eritematoso sistémico Factor de necrosis tumoral Promotor Tnf-alfa Esclerosis múltiple Polimorfismos de genes Citocinas Th1 / th2 Glándulas salivales Susceptibilidad Expresión Enfermedad Sle tumor necrosis factor polymorphism primary Sjogren's syndrome systemic lupus erythematosus Tumor-necrosis-factor Tnf-alpha promoter Multiple-sclerosis Gene polymorphisms Th1/th2 cytokines Salivary-glands Susceptibility Expression Disease Sle Lack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjogren's syndrome article info:eu-repo/semantics/publishedVersion Artículo