2026-04-30T17:48:42Zhttps://repository.urosario.edu.co/oai/request

oai:repository.urosario.edu.co:10336/278092021-08-05T17:37:33Zcom_10336_39998com_10336_563col_10336_683

Correa, P.A. Whitworth, W.C. Kuffner, T. McNicholl, J. Anaya, Juan-Manuel 2020-08-19T14:44:00Z 2020-08-19T14:44:00Z 2002-07-22 HLA?DRB1, DRB3, DRB4, DRB5 and DQB1 polymorphisms were studied using molecular methods in a population of 100 unrelated healthy individuals from an area in north?west Colombia (Medellin) inhabited by the “Paisa”, a community with features of a genetically isolated group. The most frequently observed specificities at the DRB1 locus were *07 (16.4%) and *15 (12%), and at the DQB1 locus *02 (18.8%) and *03 (33.6%), of which *0302 was the most prevalent allele (14.3%). The most polymorphic specificities were DRB1*04, 13 and 11, and DQB1*06. Both the HLA?DRB1 and DQB1 loci were in linkage disequilibrium. Haplotypes were estimated using maximum likelihood methods. The most frequent two locus haplotype was DRB1*07?DQB1*02 (6.6%) and these specificities were in linkage disequilibrium. Several unusual possible haplotypes were observed. Both the HLA?DRB1 and DQB1 locus were in Hardy–Weinberg equilibrium. application/pdf https://doi.org/10.1034/j.1399-0039.2002.590515.x ISSN: 1399-0039 EISSN: 2059-2310 https://repository.urosario.edu.co/handle/10336/27809 eng European Federation for Immunogenetics John Wiley & Sons 439 No. 5 436 HLA, Tissue Antigens Vol. 59 HLA, Tissue Antigens, ISSN: 1399-0039;EISSN: 2059-2310, Vol.59, No.5 (May 2002); pp. 436-439 https://onlinelibrary.wiley.com/doi/epdf/10.1034/j.1399-0039.2002.590515.x info:eu-repo/semantics/restrictedAccess Restringido (Acceso a grupos específicos) HLA, Tissue Antigens instname:Universidad del Rosario reponame:Repositorio Institucional EdocUR Colombia HLA?Class II Population study PCR?SSP HLA-DR and DQB1 gene polymorphism in the North-western Colombian population Polimorfismo de los genes HLA-DR y DQB1 en la población del noroeste de Colombia article info:eu-repo/semantics/publishedVersion Artículo